{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:17:13Z","timestamp":1787167033877,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,4,21]],"date-time":"2005-04-21T00:00:00Z","timestamp":1114041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To verify whether the decreasing neural tube defects birth prevalence rates in Chile are due to folic acid fortification or to pre\u2010existing decreasing trends, we performed a population survey using a network of Estudio Colaborativo Latino Americano de Malformaciones Cong\u00e9nitas (ECLAMC, Latin American Collaborative Study of Congenital Malformations) maternity hospitals in Chile, between the years 1982 and 2002. Within each maternity hospital, birth prevalence rates of spina bifida and anencephaly were calculated from two pre\u2010fortification periods (1982\u20131989 and 1990\u20132000), and from one fortified period (2001\u20132002). There was no historical trend for spina bifida birth prevalence rates before folic acid fortification, and there was a 51% (minimum 27%, maximum 66%) decrease in the birth prevalence rates of this anomaly in the fortified period. The relative risks of spina bifida were homogeneous among hospitals in the two period comparisons. There was no historical trend for the birth prevalence of anencephaly comparing the two pre\u2010fortified periods, but the relative risks were heterogeneous among hospitals in this comparison. There was a 42% (minimum 10%, maximum 63%) decrease in the birth prevalence rate of anencephaly in the fortified period as compared with the immediately pre\u2010fortified period, with homogeneous relative risks among hospitals. Within the methodological constraints of this study we conclude that the birth prevalence rates for both spina bifida and anencephaly decreased as a result of folic acid fortification, without interference of decreasing secular trends. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.30651","type":"journal-article","created":{"date-parts":[[2005,4,21]],"date-time":"2005-04-21T11:46:22Z","timestamp":1114083982000},"page":"120-125","source":"Crossref","is-referenced-by-count":126,"title":["Reduction of birth prevalence rates of neural tube defects after folic acid fortification in Chile"],"prefix":"10.1002","volume":"135A","author":[{"given":"Jorge S.","family":"L\u00f3pez\u2010Camelo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00eada M.","family":"Orioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria da Gra\u00e7a","family":"Dutra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Nazer\u2010Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Elena","family":"Ojeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Canessa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Wettig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"Fontannaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cec\u00edlia","family":"Mellado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo E.","family":"Castilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,4,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320220406"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080776"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20230"},{"key":"e_1_2_5_5_1","volume-title":"Epidemiology of anencephalus and spina bifida","author":"Elwood JM","year":"1980"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.45.1.52"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/096228029300200202"},{"issue":"1","key":"e_1_2_5_8_1","first-page":"42","article-title":"Effect of folic acid fortification in Chile: Preliminary results","volume":"10","author":"Freire WB","year":"2000","journal-title":"Eur J Pediatr Surg"},{"key":"e_1_2_5_9_1","first-page":"237","article-title":"Incidence of neural tube defects in Ontario, 1986\u20131999","volume":"167","author":"Gucciardi E","year":"2002","journal-title":"CMAJ"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.10.3166"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.23.2981"},{"key":"e_1_2_5_12_1","first-page":"41","volume-title":"Congenital malformations worldwide","author":"ICBDMS","year":"1991"},{"key":"e_1_2_5_13_1","unstructured":"International Clearinghouse for Birth Defects Monitoring Systems.2001.Annual report 2001 with data for 1999. ICBD (The International Centre for Birth Defects) Rome (ISSN 0743\u20105703)."},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872001000500009"},{"key":"e_1_2_5_15_1","first-page":"241","article-title":"Incidence of open neural tube defects in Nova Scotia after folic acid fortification","volume":"167","author":"Persad VL","year":"2002","journal-title":"CMAJ"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.30651","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.30651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T14:53:11Z","timestamp":1697640791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.30651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,21]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1002\/ajmg.a.30651"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.30651","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,21]]}}}