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Classical cytogenetic analysis showed a partial duplication of chromosome 13q, array comparative genomic hybridization showed the duplication to span approximately 21 Mb, ranging from chromosome band 13q21.31 to 13q31.1. The relatively mild presentation of this large duplication may be explained by the relative paucity of genes in the chromosome region involved. Genotype\u2013phenotype correlations in patients with similar partial 13q duplications are inconsistent. Emerging cytogenetic techniques will allow more reliable genotype\u2013phenotype correlations. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.30758","type":"journal-article","created":{"date-parts":[[2005,5,11]],"date-time":"2005-05-11T20:47:07Z","timestamp":1115844427000},"page":"76-80","source":"Crossref","is-referenced-by-count":13,"title":["Array comparative genomic hybridization analysis of a familial duplication of chromosome 13q: A recognizable syndrome"],"prefix":"10.1002","volume":"136A","author":[{"given":"Inge B.","family":"Mathijssen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan M.N.","family":"Hoovers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri N.P.M.","family":"Mul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Yen","family":"Man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan L.","family":"Ket","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul C.M.","family":"Hennekam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,11]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"A265","article-title":"Mapping of the second locus of postaxial polydactyly type A(PAP\u2010A2) to chromosome 13q21\u201032. 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