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We describe a familial rearrangement der(1)del(1)(p36.33)dup(1)(p36.33p36.22) identified in a mother, daughter, and son. These individuals help define a syndrome with variable mental disability, attention deficit\u2010hyperactivity disorder, and a distinctive facial appearance with wide palpebral fissures, broad nasal root, macrostomia, ear malformations, and prominent incisors. Based on our results we suggest that the complex rearrangement seen in our family could be the result of the breakage\u2010fusion\u2010bridge (BFB) cycles model of formation. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.30958","type":"journal-article","created":{"date-parts":[[2005,11,16]],"date-time":"2005-11-16T19:55:51Z","timestamp":1132170951000},"page":"136-140","source":"Crossref","is-referenced-by-count":17,"title":["Molecular cytogenetic characterization of a familial der(1)del(1)(p36.33)dup(1)(p36.33p36.22) with variable phenotype"],"prefix":"10.1002","volume":"139A","author":[{"given":"Vijay S.","family":"Tonk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Golder N.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana 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