{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:07:41Z","timestamp":1767650861895},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T00:00:00Z","timestamp":1133827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although earlier studies on pregnancies derived through intracytoplasmic sperm injection (ICSI) reported increased non\u2010mosaic aneuploidy among ICSI children, undetected mosaicism, such as confined placental mosaicism (CPM) has not been evaluated. We investigated the incidence of CPM in post\u2010delivery placentas derived from ICSI, evaluated whether CPM was increased and whether it was a contributing factor to negative pregnancy outcome. [Fifty\u2010one post\u2010delivery placentas were collected from patients who underwent ICSI with a normal or negative pregnancy outcome]. Trophoblast and chorionic stroma from three sites were analyzed by comparative genomic hybridization (CGH) and flow cytometry. Detected abnormalities were confirmed by fluorescence in situ hybridization (FISH). The incidence of CPM in the ICSI population was compared to the general population from published data. We detected three cases of CPM in our study. One abnormality was found by CGH analysis; partial trisomy 7q and a partial monosomy Xp limited to the trophoblast at two sites. The abnormality was associated with a child affected by spina bifida. Two cases of mosaic tetraploidy were observed by flow cytometry in pregnancies with a normal outcome. All three abnormalities were confirmed by FISH analysis. The incidence of CPM in the ICSI study population was 5.88% (3\/51), which was not statistically different from published reports in the general population (5.88% (42\/714), Chi square, <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). The post\u2010ICSI population was not at risk for CPM in this study. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.31016","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T21:17:05Z","timestamp":1133903825000},"page":"24-30","source":"Crossref","is-referenced-by-count":6,"title":["Investigation of confined placental mosaicism (CPM) at multiple sites in post\u2010delivery placentas derived through intracytoplasmic sperm injection (ICSI)"],"prefix":"10.1002","volume":"140A","author":[{"given":"Agata","family":"Minor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karynn","family":"Harmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basil Ho","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sai","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.398"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970151210"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.5858\/2001-125-0081-CGH","article-title":"Comparative genomic hybridization. A new tool for reproductive pathology","volume":"125","author":"Barrett IJ","year":"2001","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000073410"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320460517"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.10.2600"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh592"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod55.6.1253"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(02)00151-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.502"},{"key":"e_1_2_6_12_1","first-page":"207","article-title":"A prospective cytogenetic study in third trimester placentas of fetuses with unexplained intrauterine growth restriction","volume":"6","author":"Cowles TA","year":"1996","journal-title":"J Matern Fetal Invest"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(200003)20:3<190::AID-PD777>3.0.CO;2-A"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02281877"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-197409000-00029"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1359641"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6867735"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.33.7.529"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970130405"},{"key":"e_1_2_6_20_1","first-page":"47","article-title":"Chromosome and interphase analysis of placental mosaicism in intrauterine growth retardation","volume":"15","author":"Krishnomoorthy A","year":"1995","journal-title":"J Perinatol"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)02873-4"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91277-3"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199608)16:8<705::AID-PD930>3.0.CO;2-6"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.79.3.F223"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199905)59:5<325::AID-TERA3>3.0.CO;2-N"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)01799-X"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.6.1100"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2003.015784"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.104923"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.01.052"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod51.3.373"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92425-F"},{"key":"e_1_2_6_33_1","first-page":"917","article-title":"Meiotic origin of trisomy in confined placental mosaicism correlated with presence of fetal uniparental mosaicism, high levels of trisomy in trophoblast, and increased risk of fetal intrauterine growth restriction","volume":"60","author":"Robinson WP","year":"1997","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_34_1","first-page":"107","article-title":"DNA flow cytometric analysis of abortions. A simple method for detection of triploidy and tetraploidy in the trophoblastic cells","volume":"87","author":"Rua S","year":"1995","journal-title":"Pathologica"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970141304"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000053871"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)04701-5"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh007"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61652-5"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/8.2.111"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.2.351"},{"key":"e_1_2_6_42_1","first-page":"52","article-title":"Chorionic chromosome abnormalities and intrauterine growth retardation","volume":"10","author":"Verp MS","year":"1990","journal-title":"J Perinatol"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.5.1189"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90082-9"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199606)16:6<511::AID-PD904>3.0.CO;2-8"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.31016","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.31016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T05:49:47Z","timestamp":1700027387000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.31016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12,6]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1002\/ajmg.a.31016"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.31016","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12,6]]}}}