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We observed that the phenotype was highly variable, even in two families with three 1st degree relatives. Among the 14 individuals, general intelligence varied from normal to severe mental retardation. The more common features of 18q\u2010deletions (e.g., foot deformities, aural atresia, palatal abnormalities, dysmyelination, and nystagmus) were present in individuals lacking only the distal portion 18q22.3\u2010qtel. Interstitial deletions exerted very heterogeneous effects on phenotype. In individuals with distal 18q22.3\u2010q23 deletions, brain MRI was very distinctive with poor differentiation of gray and white matter on T2\u2010weighted images. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.31072","type":"journal-article","created":{"date-parts":[[2006,1,18]],"date-time":"2006-01-18T02:46:44Z","timestamp":1137552404000},"page":"331-339","source":"Crossref","is-referenced-by-count":57,"title":["18q deletions: Clinical, molecular, and brain MRI findings of 14 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