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Using chromosomal microdissection, locus\u2010specific fluorescence in situ hybridization (FISH), and PCR with several Y\u2010chromosome markers, the larger supernumerary marker chromosome (SMC) was characterized as a ring Y\u2010chromosome. Detection of the SRY\u2010region explained the male phenotype. The smaller second marker chromosome contained the pericentromeric region of chromosome 8. We suggest that the co\u2010occurrence of a partial Y\u2010chromosome and partial trisomy 8 explain the severe speech delay and the facial dysmorphic features. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.31104","type":"journal-article","created":{"date-parts":[[2006,2,9]],"date-time":"2006-02-09T23:17:33Z","timestamp":1139527053000},"page":"488-495","source":"Crossref","is-referenced-by-count":4,"title":["Characterization of two supernumerary marker chromosomes in a patient with signs of Klinefelter syndrome, mild facial anomalies, and severe speech 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