{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:26:28Z","timestamp":1786976788037,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,2,6]],"date-time":"2006-02-06T00:00:00Z","timestamp":1139184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2006,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Primary palmar hyperhidrosis (PPH) is a unique disorder of unknown cause. It is characterized by excessive perspiration of the eccrine sweat gland in the palm, sole, and the axilla. It is presumed that PPH results from overactivation of the cholinergic sympathetic nerve or dysfunction of the autonomic nervous system. There have been no genetic studies on the disease. We performed a linkage analysis of 11 families including 42 affected and 40 unaffected members using genome\u2010wide DNA polymorphic markers to identify the disease locus. Diagnosis of their PPH was made by direct inspection, interviewing and measurement of the sweating rate with perspirometer. Consequently, from data of three of the 11 families examined, the combined maximum two\u2010point LOD scores of 3.08 and 3.16 (recombination fraction\u2009=\u20090) were obtained at the\n                    <jats:italic>D14S283<\/jats:italic>\n                    and\n                    <jats:italic>D14S264<\/jats:italic>\n                    loci, respectively, on chromosome 14q11.2\u2010q13, under an assumption that two liability conditions depend on age. These regions were ruled out in eight other families. Haplotype analysis of the three families supported that one of the PPH locus is assigned at minimum to about a 6\u2010cM interval between\n                    <jats:italic>D14S1070<\/jats:italic>\n                    and\n                    <jats:italic>D14S990<\/jats:italic>\n                    and at maximum to about a 30\u2010cM interval between\n                    <jats:italic>D14S1070<\/jats:italic>\n                    and\n                    <jats:italic>D14S70<\/jats:italic>\n                    . This is the first report of systemic mapping of the PPH locus. \u00a9 2006 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.a.31127","type":"journal-article","created":{"date-parts":[[2006,2,9]],"date-time":"2006-02-09T17:21:47Z","timestamp":1139505707000},"page":"567-572","source":"Crossref","is-referenced-by-count":54,"title":["Primary palmar hyperhidrosis locus maps to 14q11.2\u2010q13"],"prefix":"10.1002","volume":"140A","author":[{"given":"Ikuyo","family":"Higashimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koh\u2010ichiro","family":"Yoshiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Hirakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Higashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenobu","family":"Soejima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadahide","family":"Totoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunehiro","family":"Mukai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Niikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197707000-00006"},{"key":"e_1_2_6_3_1","first-page":"243","article-title":"Linkage analysis of the nail\u2010patella syndrome","volume":"56","author":"Campeau E","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1952.tb16160.x"},{"key":"e_1_2_6_5_1","first-page":"381","article-title":"Treatment of hyperhidrosis palmaris (sweaty hands): A familial disease in Japanese","volume":"16","author":"Cloward RB","year":"1957","journal-title":"Hawaii Med J"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0598-47"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1013863"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)04657-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005950050047"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.71.6.2453"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1001\/archderm.1987.01660310093022","article-title":"Emotional eccrine sweating. 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