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He has an elongated face, sparse hair, upslanting palpebral fissures, anteverted nostrils, hypoplastic thumbs on both hands, and dislocation of several joints. His chromosome aberration was diagnosed at birth and was due to an unbalanced segregation of a maternal translocation t(2;16)(q36;p11). At 26 years of age he is, to the best of our knowledge, the oldest patient with duplication of 16p reported to date. We present a long\u2010term observation of growth, psychomotor development, dysmorphic features and evolution of his skeletal and joint defects as well as a review of the literature. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.31605","type":"journal-article","created":{"date-parts":[[2007,1,17]],"date-time":"2007-01-17T20:18:03Z","timestamp":1169065083000},"page":"399-408","source":"Crossref","is-referenced-by-count":13,"title":["Long\u2010term follow\u2010up of a 26\u2010year\u2010old male with duplication of 16p: Clinical report and review"],"prefix":"10.1002","volume":"143A","author":[{"given":"Mascha K.","family":"Rochat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariluce","family":"Riegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert A.","family":"Schinzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320380102"},{"key":"e_1_2_6_3_1","first-page":"233","article-title":"Identification par les bandes Q et G des anomalies chromosomiques dans les avortements spontan\u00e9s","volume":"19","author":"Bou\u00e9 J","year":"1976","journal-title":"Ann G\u00e9n\u00e9t"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.31.3.234"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(67)90488-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970120)68:2<219::AID-AJMG19>3.0.CO;2-X"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199908)19:8<783::AID-PD635>3.0.CO;2-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320140114"},{"key":"e_1_2_6_9_1","first-page":"1","article-title":"\u201cDe novo\u201d trisomy 16p11\u2010>pter","volume":"49","author":"Dallapiccola B","year":"1979","journal-title":"Hum Genet"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2005.05.009"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10287"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1981.tb00665.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320540316"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320210320"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00293904"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-3995(00)01021-2"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2005.01.007"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1979.tb00991.x"},{"key":"e_1_2_6_19_1","first-page":"587","article-title":"Trisom\u00eda partial 16p \u201cde novo\u201d","volume":"15","author":"Llamas JG","year":"1981","journal-title":"An Esp Pediatr"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320430324"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1976.tb01564.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.21.4.315"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320260130"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002469900278"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320420311"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960111)61:2<117::AID-AJMG2>3.0.CO;2-U"},{"key":"e_1_2_6_27_1","first-page":"138A","article-title":"Trisomy 16p\u2010 a distinct phenotype","volume":"34","author":"Rada D","year":"1982","journal-title":"Am J Med Genet"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.15.5.375"},{"key":"e_1_2_6_29_1","volume-title":"Catalogue of unbalanced chromosome aberrations in man","author":"Schinzel A","year":"2001"},{"key":"e_1_2_6_30_1","unstructured":"SchinzelA.2005. 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