{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:54:05Z","timestamp":1791136445907,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2007,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report on a young male with moderate mental retardation, dysmorphic features, and language delay who is deleted for 7q31.1\u20107q31.31. His full karyotype is 46,XY,der(7)del(7)(q31.1q31.31)ins(10;7)(q24.3;q31.1q31.31)mat. This child had language impairment, including developmental verbal dyspraxia, but did not meet criteria for autism according to standardized ADOS testing. Our patient's deletion, which is the smallest reported deletion including <jats:italic>FOXP2<\/jats:italic>, adds to the body of evidence that supports the role of <jats:italic>FOXP2<\/jats:italic> in speech and language impairment, but not in autism. A reported association between autism and deletions of <jats:italic>WNT2<\/jats:italic>, a gene also deleted in our patient, is likewise not supported by our case. Previously, fine mapping with microsatellites markers within in a large three\u2010generation family, in which half the members had severe specific language impairment, aided the localization of the <jats:italic>SPCH1<\/jats:italic> locus to 7q31 within markers D7S2459 (107.1 Mb) and D7S643 (120.5 Mb). Additionally, chromosome rearrangement of 7q31 and mutational analyses have supported the growing evidence that <jats:italic>FOXP2<\/jats:italic>, a gene within the <jats:italic>SPCH1<\/jats:italic> region, is involved with speech and language development. It is unclear however whether the <jats:italic>AUTS1<\/jats:italic> (autistic spectrum 1) locus, highly linked to 7q31, overlaps with the <jats:italic>SPCH1<\/jats:italic> and <jats:italic>FOXP2<\/jats:italic>. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.31632","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:10:17Z","timestamp":1172794217000},"page":"791-798","source":"Crossref","is-referenced-by-count":73,"title":["Deletion of 7q31.1 supports involvement of <i>FOXP2<\/i> in language impairment: Clinical report and 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