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Evidence for each of these classes of candidate genes is reviewed in detail. As this review indicates, a number of genetically controlled pathways appear to be involved in at least some cases of SIDS. Given the diversity of results to date, genetic studies support the clinical impression that SIDS is heterogeneous with more than one entity and with more than one possible genetic etiology. Future studies should consider expanded phenotypic features that might help clarify the heterogeneity and improve the predictive value of the identified genetic factors. Such features should be evaluated to the extent possible in both SIDS victims and their family members. With 2,162 infants dying from SIDS in 2003 in the U.S. alone, and improved but still imperfect parent and caretaker compliance with known modifiable risk factors for SIDS, it behooves clinicians, researchers, and parents to combine efforts to reach a common goal. The message of the \u201cBack to Sleep\u201d campaign needs to be re\u2010introduced\/re\u2010engineered to reach families and caretakers of all ethnic groups. Clinicians and researchers need to gently inform new SIDS parents about the opportunity to contribute tissue to the NICHD\u2010funded University of Maryland Brain and Tissue Bank. By expanding the network of clinicians, scientists, and families working together, and by combined efforts in a collaborative multi\u2010center study of candidate genes and\/or genomics, the discovery of the genetic profile of the infant at risk for SIDS can ultimately be determined. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.31722","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T21:18:25Z","timestamp":1173129505000},"page":"771-788","source":"Crossref","is-referenced-by-count":111,"title":["Sudden Infant Death Syndrome: Review of implicated genetic factors"],"prefix":"10.1002","volume":"143A","author":[{"given":"Debra E.","family":"Weese\u2010Mayer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Ackerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary 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