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The purpose of this study was to define and differentiate the behavioral phenotype of autism in samples of children with either (VCFS) or idiopathic autism. Five groups of children ages 5\u201315 were included in the between\u2010group design. Parent report of autism behaviors (based on the Autism Diagnostic Interview\u2010Revised, ADI\u2010R) were compared between children with VCFS, children with VCFS and autism (VCFS\u2009+\u2009autism), siblings of the children with VCFS, a community control group, and a group of children with idiopathic autism. Autism diagnoses were based according to the ADI\u2010R. Parental responses to the ADI\u2010R indicated that relative to children with VCFS\u2010only, children with idiopathic autism and children with VCFS\u2009+\u2009autism exhibited less make believe play and more rituals, motor stereotypies and repetitive use of objects. However several other core autism behaviors, including difficulties sharing attention, deficits in gestural communication and initiating conversation, and presence of circumscribed interests, appear to be phenotypic VCFS behaviors, characterizing children with VCFS regardless of an autism diagnosis. Accordingly, the autism phenotype in VCFS differs to some extent from that of idiopathic autism. Several features of idiopathic autism are spared in VCFS, and other features appear to be a function of the VCFS phenotype independent of autism. These findings carry implications for clinicians who diagnose and treat VCFS or autism, and for researchers who study genotype\u2013phenotype associations in autism. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.32012","type":"journal-article","created":{"date-parts":[[2007,10,16]],"date-time":"2007-10-16T01:16:48Z","timestamp":1192497408000},"page":"2642-2650","source":"Crossref","is-referenced-by-count":74,"title":["Comparing phenotypes in patients with idiopathic autism to patients with velocardiofacial syndrome (22q11 DS) with and without autism"],"prefix":"10.1002","volume":"143A","author":[{"given":"Wendy R.","family":"Kates","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin M.","family":"Antshel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanda 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