{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:26:15Z","timestamp":1782311175040,"version":"3.54.5"},"reference-count":97,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,3,17]],"date-time":"2008-03-17T00:00:00Z","timestamp":1205712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2008,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Dutch\u2010German Mennonites are a religious isolate with foundational roots in the 16th century. A tradition of endogamy, large families, detailed genealogical records, and a unique disease history all contribute to making this a valuable population for genetic studies. Such studies in the Dutch\u2010German Mennonite population have already contributed to the identification of the causative genes in several conditions such as the incomplete form of X\u2010linked congenital stationary night blindness (CSNB2; previously iCSNB) and hypophosphatasia (HOPS), as well as the discovery of founder mutations within established disease genes (<jats:italic>MYBPC1<\/jats:italic>, <jats:italic>CYP17\u03b1<\/jats:italic>). The Dutch\u2010German Mennonite population provides a strong resource for gene discovery and could lead to the identification of additional disease genes with relevance to the general population. In addition, further research developments should enhance delivery of clinical genetic services to this unique community. In the current review we discuss 31 genetic conditions, including 17 with identified gene mutations, within the Dutch\u2010German Mennonite population. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.32061","type":"journal-article","created":{"date-parts":[[2008,3,17]],"date-time":"2008-03-17T20:08:13Z","timestamp":1205784493000},"page":"1072-1087","source":"Crossref","is-referenced-by-count":35,"title":["Unique disease heritage of the Dutch\u2010German Mennonite population"],"prefix":"10.1002","volume":"146A","author":[{"given":"Noelle C.","family":"Orton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Micheil","family":"Innes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert E.","family":"Chudley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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