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We report on a newborn infant with previously undescribed findings, including hydrops fetalis, primary pulmonary hypertension and unusually severe abnormalities of toes. We review clinical data on 22 published cases in order to delineate the phenotype of this condition. Clinical recommendations for prenatal and postnatal evaluation of patients and fetuses at risk are discussed. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.32135","type":"journal-article","created":{"date-parts":[[2008,1,17]],"date-time":"2008-01-17T22:50:52Z","timestamp":1200610252000},"page":"532-537","source":"Crossref","is-referenced-by-count":20,"title":["Yunis\u2013Varon syndrome: Further delineation of the phenotype"],"prefix":"10.1002","volume":"146A","author":[{"given":"Lina","family":"Basel\u2010Vanagaite","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liora","family":"Kornreich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Schiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Yacobovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Merlob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.30.9.788"},{"key":"e_1_2_7_3_1","first-page":"373","article-title":"Yunis\u2010Varon syndrome","volume":"42","author":"Bhatia S","year":"2005","journal-title":"Indian Pediatr"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199909000-00025"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(94)00089-R"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.27.2.114"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.26.1.55"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320140318"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02825832"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90324-J"},{"key":"e_1_2_7_11_1","first-page":"224","article-title":"Cardiomyopathy added to the Yunis Varon syndrome","volume":"7","author":"Partington MW","year":"1988","journal-title":"Proc Greenwood Genet"},{"key":"e_1_2_7_12_1","first-page":"241","article-title":"Aplasia of the thumbs and great toes as the outstanding feature of Yunis and Varon syndrome. 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A new observation","volume":"31","author":"Pfeiffer RA","year":"1988","journal-title":"Ann Genet"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019605-199607000-00005"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20414"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20001113)95:2<157::AID-AJMG12>3.0.CO;2-E"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1980.02130190017005"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.32135","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.32135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T08:25:39Z","timestamp":1697617539000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.32135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,17]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,2,15]]}},"alternative-id":["10.1002\/ajmg.a.32135"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.32135","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,17]]}}}