{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T16:27:25Z","timestamp":1779294445553,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2008,7,14]],"date-time":"2008-07-14T00:00:00Z","timestamp":1215993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2008,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Predictive genetic testing for Huntington disease (HD) might cause severe short\u2010term psychological reactions in patients with poor mental health. Very few studies exist on the long\u2010term effects of genetic HD testing. The aim of this study was to assess mental health and quality of life in persons who were tested for HD mutation, to compare mental health depending on the result of the genetic test (non\u2010carriers, gene carriers, and patients with HD) and to identify predictors of mental health and quality of life via linear regression. The data were collected by self\u2010report questionnaires. In total, 121 individuals participated in this study: 52 were non\u2010carriers, 54 were gene carriers, and 15 were gene carriers suffering from HD. Non\u2010carriers and gene carriers showed better mental health and quality of life than HD\u2010patients but did not differ from each other. In non\u2010carriers four variables predicted increased depression and low mental quality of life: low perceived social support, no intimate relationship, female sex and younger age. For gene carriers three predictors were found: low perceived social support, the expectation of an unfavorable genetic test result before the testing procedure and being childless. To prevent detrimental effects of HD testing on mental health and mental quality of life, specific attention should be paid to persons with limited social networks during genetic counseling. Assessment of expectations related to the test result and mental health prior to a genetic testing procedure may help to identify gene carriers at risk of poor coping after an unfavorable test result. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.32423","type":"journal-article","created":{"date-parts":[[2008,7,15]],"date-time":"2008-07-15T00:43:36Z","timestamp":1216082616000},"page":"2078-2085","source":"Crossref","is-referenced-by-count":37,"title":["Mental health and quality of life after genetic testing for Huntington disease: A long\u2010term effect study in Germany"],"prefix":"10.1002","volume":"146A","author":[{"given":"Claudia","family":"Licklederer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Barth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/302374"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2003.00157.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.20.2.112"},{"key":"e_1_2_6_5_1","volume-title":"BDI\u2010II. 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