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Postnatal brain computerized tomography (CT) presented cortical band\u2010like calcification, calcification of basal ganglia and brain stem while brain magnetic resonance imaging (MRI) revealed abnormal gyral pattern, marked loss of white matter, dysplastic ventricles, polymicrogyria, hypogenesis of corpus callosum and cerebellar hypoplasia. No abnormalities of the internal organs, eye, or skeleton were found to be associated with this syndrome. Fetal Magnetic resonance imaging helped reaching the diagnosis in utero in one patient. Three patients died in the first years of life while the others within days after birth preceded by high fever and status epilepticus. These patients present many overlapping features with pseudo TORCH syndrome, however, the imaging findings are quite different. We propose that the distinct pattern in these sibs constitutes genetic disorder of microcephaly, developmental brain malformation and intracranial calcification of likely autosomal recessive inheritance. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.32549","type":"journal-article","created":{"date-parts":[[2008,10,17]],"date-time":"2008-10-17T01:06:29Z","timestamp":1224205589000},"page":"2929-2936","source":"Crossref","is-referenced-by-count":27,"title":["Microcephaly, malformation of brain development and intracranial calcification in sibs: Pseudo\u2010TORCH or a new syndrome"],"prefix":"10.1002","volume":"146A","author":[{"given":"Ghada M.H.","family":"Abdel\u2010Salam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha S.","family":"Zaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar 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