{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:27:28Z","timestamp":1786976848871,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,2,12]],"date-time":"2009-02-12T00:00:00Z","timestamp":1234396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tuberous sclerosis complex (TSC) (OMIM191100) is a genetic disorder with multi\u2010system involvement including neurodevelopmental manifestations. There is great interest in understanding the pathogenetic mechanisms underlying these neurobehavioral and neurocognitive manifestations. However, there are still significant gaps in knowledge about the exact neuropsychiatric phenotypes observed in TSC. Here we report on the first systematic evaluation of neuropsychological attentional skills in a population\u2010derived sample of children and adolescents with TSC. The study showed that, even when age, gender, IQ, and intra\u2010familial clustering were controlled for, the TSC group had significantly lower scores than their unaffected siblings on a range of neuropsychological attentional tasks, and that they had significantly more neuropsychological attention deficits. Eighteen of the 20 children (90%) showed deficits on one or more attentional tasks, with dual task performance most consistently impaired (85%) and visual selective attention a relative strength. Active seizures and anti\u2010epilepsy medication did not influence attentional profiles. Furthermore, parent rating of attention\u2010related behaviors were not able to identify children at risk of neuropsychological deficits. The findings suggest that clinical neuropsychological evaluation of attentional skills should be performed in children and adolescents with TSC even when they have normal global intellectual abilities, no seizures, and no disruptive behaviors. Results suggest that the mechanisms underlying these deficits may include contributions from structural, seizure\u2010related and molecular factors. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.32690","type":"journal-article","created":{"date-parts":[[2009,2,12]],"date-time":"2009-02-12T18:53:15Z","timestamp":1234464795000},"page":"387-395","source":"Crossref","is-referenced-by-count":40,"title":["Neuropsychological attention deficits in tuberous sclerosis complex (TSC)"],"prefix":"10.1002","volume":"149A","author":[{"given":"Petrus J.","family":"de Vries","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Gardiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick F.","family":"Bolton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/09297049508400224"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/713755569"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/026990598121990"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf124"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0033-8389(22)01039-9","article-title":"The central system manifestations of the phacomatoses on MR","volume":"26","author":"Braffman BH","year":"1988","journal-title":"Radiol Clin North Am"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2214.2006.00630.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","unstructured":"ConnersC.1997.Conners' Rating Scales\u2010Revised. 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