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Most patients also show impaired social interaction with avoidance of eye\u2010to\u2010eye contact, and some clinical features reminiscent of Rett syndrome (RTT), including stereotypic hand movements, lack of purposeful hand use, acquired microcephaly, and generalized hypotonia. We report on the case of a 5\u2010year\u2010old girl with a de novo <jats:italic>CDKL5<\/jats:italic> gene mutation who developed early puberty, which has not been described before. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.32806","type":"journal-article","created":{"date-parts":[[2009,4,27]],"date-time":"2009-04-27T22:41:04Z","timestamp":1240872064000},"page":"1046-1051","source":"Crossref","is-referenced-by-count":19,"title":["A <i>CDKL5<\/i> mutated child with precocious 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