{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:38:36Z","timestamp":1767850716240,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There has been a long\u2010running debate about the association between paternal age and Down syndrome. Some studies have failed to adequately control for maternal age, and have suffered from high levels of missing paternal age, raising concerns over selection bias. This paper analyzes an anonymously case\u2010controlled dataset with 98% complete parental age data, originally collected to investigate the association between parental exposure to radiation and Down syndrome. In our methods the cases and controls were matched on maternal age to within 6 months, and conditional logistic regression was used to estimate the odds ratio associated with a 10\u2010year increase in paternal age. Our results showed the estimated odds ratio for a Down syndrome pregnancy associated with a 10\u2010year increase in paternal age was 1.13, 95%CI (0.85, 1.52). There was no statistically significant evidence of an association between paternal age and Down syndrome, but the estimated association was positive. The size of the estimated effect is much smaller than the effect of maternal age. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.32850","type":"journal-article","created":{"date-parts":[[2009,5,16]],"date-time":"2009-05-16T00:14:24Z","timestamp":1242432864000},"page":"1205-1208","source":"Crossref","is-referenced-by-count":17,"title":["Down syndrome and paternal age, a new analysis of case\u2013control data collected in the 1960s"],"prefix":"10.1002","volume":"149A","author":[{"given":"Elizabeth","family":"De Souza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Alberman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan K.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1972.tb00769.x"},{"key":"e_1_2_5_3_1","first-page":"544","article-title":"The meiotic stage of nondisjunction in trisomy 21: Determination by using DNA polymorphisms","volume":"50","author":"Antonarakis SE","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20316"},{"key":"e_1_2_5_5_1","volume-title":"Statistical methods in cancer research volume 1\u2014The analysis of case\u2010control studies","author":"Breslow NE","year":"1980"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20011001)103:2<149::AID-AJMG1525>3.0.CO;2-G"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1978.tb01896.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.18.1.22"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2000.570201.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00282309"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00291570"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3016.2002.00446.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2003.10.003"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00329126"},{"key":"e_1_2_5_15_1","first-page":"648","article-title":"Paternal age and the occurrence of birth defects","volume":"39","author":"Lian ZH","year":"1986","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199505000-00016"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jms.9.1.2"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.568"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.2.313"},{"key":"e_1_2_5_20_1","first-page":"1297","article-title":"An analysis for paternal\u2010age effect in Ohio's Down syndrome births, 1970\u20131980","volume":"35","author":"Roecker GO","year":"1983","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420440409"},{"key":"e_1_2_5_22_1","first-page":"608","article-title":"Trisomy 21: Association between reduced recombination and nondisjunction","volume":"49","author":"Sherman SL","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del453"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei186"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.32850","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.32850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T04:26:49Z","timestamp":1697603209000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.32850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,15]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1002\/ajmg.a.32850"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.32850","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,15]]}}}