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Both these features hitherto unreported add to the phenotypic spectrum of the condition. The underlying etiopathogenesis of this condition has remained in the domain of hypothesis, with none being conclusive. Based on the characteristic features of AOS and our report of delayed bone age, we postulate a role played by the bone morphogenetic protein pathway in the causation of this enigmatic condition. In the background of this postulation and the report of an unusual hand anomaly, a literature review on the various pathogenetic mechanisms and anomalies of the hand reported in AOS is presented. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.32938","type":"journal-article","created":{"date-parts":[[2009,7,18]],"date-time":"2009-07-18T06:11:18Z","timestamp":1247897478000},"page":"1678-1684","source":"Crossref","is-referenced-by-count":15,"title":["Adams\u2013Oliver syndrome: Additions to the clinical features and possible role of BMP pathway"],"prefix":"10.1002","volume":"149A","author":[{"given":"Shankar","family":"Baskar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muralidhar Laxmanrao","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akhil 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