{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T02:49:29Z","timestamp":1770346169659,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,12,11]],"date-time":"2009-12-11T00:00:00Z","timestamp":1260489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Floating\u2010Harbor syndrome is a rare syndrome of unknown etiology, which was first described in 1973. A triad of main features characterizes Floating\u2010Harbor syndrome: short stature, characteristic face, and an expressive speech delay. We present a patient in whom the hearing thresholds improved insufficiently after placement of grommets. High\u2010resolution CT scan of the temporal bone showed a prominent soft\u2010tissue thickening suspected of causing fixation of the malleus, and fusion of the malleus head with the body of the incus. To our knowledge this is the first reported abnormal middle ear anatomy in a patient with Floating\u2010Harbor syndrome. A conservative treatment with hearing aids was preferred as an initial treatment in favor of a surgical exploration. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.33033","type":"journal-article","created":{"date-parts":[[2009,12,11]],"date-time":"2009-12-11T22:05:06Z","timestamp":1260569106000},"page":"161-164","source":"Crossref","is-referenced-by-count":7,"title":["Floating\u2010Harbor syndrome associated with middle ear abnormalities"],"prefix":"10.1002","volume":"152A","author":[{"given":"Jan\u2010Jaap","family":"Hendrickx","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathelijn","family":"Keymolen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Desprechins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Casselman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans","family":"Gordts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,12,23]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30303"},{"key":"e_1_2_4_3_1","first-page":"1157","article-title":"A mutation causing Alport syndrome with tardive hearing loss is common in the western United States","volume":"58","author":"Barker DF","year":"1996","journal-title":"Am J Hum Genet"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31159"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70075-3"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2008.08.007"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940211100309"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940211101014"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02079072"},{"key":"e_1_2_4_10_1","first-page":"2","article-title":"Case report 12","author":"Leisti J","year":"1974","journal-title":"Syndr Ident"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000150692.23506.b7"},{"key":"e_1_2_4_12_1","first-page":"1","article-title":"Case report I [abstract]","author":"Pelletier G","year":"1973","journal-title":"Syndr Ident"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200301000-00013"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80384-6"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.20.4.483.1472"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0b013e31815d63a5"},{"key":"e_1_2_4_17_1","article-title":"Verification of malleus head fixation: Computed tomography as diagnosis standard","author":"Waldeck S","year":"2008","journal-title":"HNO."},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31818208ad"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.33033","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.33033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:35:28Z","timestamp":1697056528000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.33033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,23]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.1002\/ajmg.a.33033"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.33033","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,23]]}}}