{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:27:42Z","timestamp":1786976862026,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,12,23]],"date-time":"2009-12-23T00:00:00Z","timestamp":1261526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    M\u00e9ni\u00e8re disease (MD) is a complex disorder of unknown etiology characterized by the symptom triad of vertigo, sensorineural hearing loss, and tinnitus. Its reported incidence is 1\u20132 per 1,000 in Caucasians and 0.03\u20130.37 per 1,000 in Japanese. Doi et al. [Doi et al. (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib11\">2005<\/jats:ext-link>\n                    ); ORL J Otorhinolaryngol Relat Spec 67:289\u2013293] recently reported that two single nucleotide polymorphisms (SNPs) in\n                    <jats:italic>KCNE1<\/jats:italic>\n                    and\n                    <jats:italic>KCNE3<\/jats:italic>\n                    are associated with MD in Japanese subjects. Consistent with this possibility, these two genes encode potassium channels that are expressed in the stria vascularis and endolymphatic sac, respectively, and their role in ion transport suggests that they may be important in inner ear homeostasis. To establish whether a similar association exists in the Caucasian MD population, we sequenced the coding regions and exon\u2013intron boundaries of both genes in 180 Caucasian persons with MD and 180 matched Caucasian controls. Neither of the two reported SNPs was significantly associated with MD when compared to the Caucasian controls (\n                    <jats:italic>KCNE1<\/jats:italic>\n                    ,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.55;\n                    <jats:italic>KCNE3<\/jats:italic>\n                    ,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.870). Comparison of allele frequencies between the Japanese MD population and our study population revealed no significant difference between groups (\n                    <jats:italic>KCNE1<\/jats:italic>\n                    ,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.90;\n                    <jats:italic>KCNE3<\/jats:italic>\n                    ,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.862), suggesting that the significant differences reported in the Japanese study arose from their control population. Six additional SNPs in both\n                    <jats:italic>KCNE1<\/jats:italic>\n                    and\n                    <jats:italic>KCNE3<\/jats:italic>\n                    were genotyped and none was associated with MD. Population stratification within our MD and Caucasian control population was excluded. Our data show that SNPs in\n                    <jats:italic>KCNE1<\/jats:italic>\n                    and\n                    <jats:italic>KCNE3<\/jats:italic>\n                    are not associated with MD in Caucasians. \u00a9 2009 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.a.33114","type":"journal-article","created":{"date-parts":[[2009,12,23]],"date-time":"2009-12-23T15:33:56Z","timestamp":1261582436000},"page":"67-74","source":"Crossref","is-referenced-by-count":39,"title":["Polymorphisms in\n                    <i>KCNE1<\/i>\n                    or\n                    <i>KCNE3<\/i>\n                    are not associated with M\u00e9ni\u00e8re disease in the Caucasian population"],"prefix":"10.1002","volume":"152A","author":[{"given":"Colleen A.","family":"Campbell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charley C.","family":"Della Santina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole C.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy B.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwaseun A.","family":"Myrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin M.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuni","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Califano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Carey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlan R.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce J.","family":"Gantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd B.","family":"Minor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.H.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,12,23]]},"reference":[{"issue":"113","key":"e_1_2_6_2_1","first-page":"181","article-title":"Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Meniere's disease","year":"1995","journal-title":"American Academy of Otolaryngology\u2010Head and Neck Foundation, Inc. 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