{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T01:18:24Z","timestamp":1747358304983},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T00:00:00Z","timestamp":1331683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CHARGE syndrome is a genetic disorder caused by a mutation in the <jats:italic>CHD7<\/jats:italic> gene on chromosome 8. Major clinical diagnostic criteria for this heterogeneous disorder include ocular coloboma, choanal atresia\/stenosis, characteristic external and internal ear abnormalities, and cranial nerve abnormalities. Patients with CHARGE syndrome often have dysphagia and are at high risk for aspiration of both upper and lower gastrointestinal secretions. The following case\u2010report describes the use of Botulinum toxin A (Botox) to reduce excess salivary secretions in a ventilator dependant infant who would have required a tracheotomy. Thereafter, Botox was used regularly (4\u20135 months) to decrease the salivary secretions. This case\u2010report is unique in that it describes the intermittent and prospective use of Botox to reduce excess salivary secretions and prevent the resulting aspiration\u2010related complications in an infant with CHARGE syndrome. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.33241","type":"journal-article","created":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T18:27:42Z","timestamp":1331749662000},"page":"828-831","source":"Crossref","is-referenced-by-count":10,"title":["Botulinum toxin injections into salivary glands to decrease oral secretions in CHARGE syndrome: Prospective case study"],"prefix":"10.1002","volume":"158A","author":[{"given":"Kim D.","family":"Blake","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jillian","family":"MacCuspie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Corsten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,14]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20010301)99:2<124::AID-AJMG1114>3.0.CO;2-9"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.10.044"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-1-34"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.2.217"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992289803700302"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32179"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2008.10.005"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(02)00381-8"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1054\/jcms.1999.0068"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2007.13"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-004-0026-1"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-007-9111-6"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2003-1104-L"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.036061"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/500273"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2008.11.011"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700209"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2007.02015.x"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10061354"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980413)76:5<402::AID-AJMG7>3.0.CO;2-O"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1407"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2005.03.030"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.33241","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.33241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T08:39:45Z","timestamp":1697618385000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.33241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,14]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1002\/ajmg.a.33241"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.33241","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,14]]}}}