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We describe a true case of familial Huntington disease (HD) in which we modified personal details to protect patient's privacy, where the proband at risk preferred not to know his disease status but wanted to know the status in his unborn child. Once we found the father to be negative, the case raised an important ethical question regarding the management of this as well as future pregnancies. This article discusses the arguments for and against the right not to know of one's carrier status, as well as professional obligations in the context of withholding unwanted information that may have direct implications not only for the patient himself but also for other family members. HD has served as a model for many other adult onset genetic diseases in terms of carrier testing guidelines. Hence, we feel it is time to revisit the issue of prenatal testing for HD and consider updating the current recommendations regarding the patient's right to \u201cgenetic ignorance\u201d, or the right not to know genetic information. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.33432","type":"journal-article","created":{"date-parts":[[2010,6,26]],"date-time":"2010-06-26T02:53:40Z","timestamp":1277520820000},"page":"1774-1780","source":"Crossref","is-referenced-by-count":15,"title":["The right to ignore genetic status of late onset genetic disease in the genomic era; Prenatal testing for Huntington disease as a 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