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Local patterning cues from the surrounding environment induce gene expression within neural crest cells, leading to formation of a diverse set of skeletal elements. Endothelin\u20101 (Edn1) is one of the primary signals that establishes the identity of neural crest cells within the mandibular portion of the first pharyngeal arch. Signaling through its cognate receptor, the endothelin\u2010A receptor, is critical for patterning the ventral\/distal portion of the arch (lower jaw) and also participates with Hox genes in patterning more posterior arches. Edn1\/Ednra signaling is highly conserved between mouse and zebrafish, and genetic analyses in these two species have provided complementary insights into the patterning cues responsible for establishing the craniofacial complex as well as the genetic basis of facial birth defect syndromes. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.33568","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T22:18:04Z","timestamp":1280873884000},"page":"2962-2973","source":"Crossref","is-referenced-by-count":94,"title":["Regulation of facial morphogenesis by endothelin signaling: Insights from mice and fish"],"prefix":"10.1002","volume":"152A","author":[{"given":"David E.","family":"Clouthier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvin","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas 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