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In this report, we describe a 16\u2010month\u2010old male with tetralogy of Fallot, bilateral second branchial arch remnants, and mild dysmorphic features. Array comparative genomic hybridization analysis revealed a less than 400\u2009kb interstitial deletion on chromosome 7p22. The deletion was confirmed by real\u2010time quantitative PCR and FISH analyses and was not detected in samples obtained from the child's parents. Molecular data from this de novo deletion, in combination with data from other isolated 7p deletions in the literature, can be used to define a less than 200\u2009kb minimal deleted region for cardiac malformations on 7p22. This minimal deleted region spans all, or portions, of the coding regions of four known genes\u2014<jats:italic>MAD1L1, FTSJ2, NUDT1<\/jats:italic>, and <jats:italic>SNX8<\/jats:italic>\u2014and may include upstream regulatory elements of <jats:italic>EIF3B<\/jats:italic>. It is likely that one or more of these five genes, alone or in combination, plays an important, yet previously uncharacterized, role in cardiac development. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.34041","type":"journal-article","created":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T19:45:25Z","timestamp":1307735125000},"page":"1729-1734","source":"Crossref","is-referenced-by-count":19,"title":["Delineation of a less than 200\u2009kb minimal deleted region for cardiac malformations on chromosome 7p22"],"prefix":"10.1002","volume":"155","author":[{"given":"Elliott G.","family":"Richards","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitisha P.","family":"Zaveri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varina 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