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Previous experiments with cell cultures and studies on animal model of MPS II suggested that gene expression\u2010targeted isoflavone therapy (GET IT), based on genistein\u2010mediated reduction of efficiency of GAG synthesis, might be a suitable therapy for this disease. In this report, we demonstrate efficacy of GET IT in connective tissue elasticity, particularly in improving the range of joint motion in seven patients with MPS II after 26 weeks of treatment with an isoflavone extract at the dose corresponding to 5\u2009mg\/kg\/day of genistein. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.34146","type":"journal-article","created":{"date-parts":[[2011,8,10]],"date-time":"2011-08-10T20:38:42Z","timestamp":1313008722000},"page":"2257-2262","source":"Crossref","is-referenced-by-count":46,"title":["Improvement in the range of joint motion in seven patients with mucopolysaccharidosis type II during experimental gene expression\u2010targeted isoflavone therapy (GET 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