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We report on the case of a 14\u2010month\u2010old boy with an apparently isolated craniosynostosis and harboring a de novo microdeletion in band 4p15. The imbalance, about 4\u2009Mb in size is, to date, the smallest deletion ever described in this region, encompassing 12 genes. A comparison with other previously described cases of 4p15 deletion is made, and the possible roles of some genes involved in the deletion are discussed. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.34201","type":"journal-article","created":{"date-parts":[[2011,9,10]],"date-time":"2011-09-10T02:46:44Z","timestamp":1315622804000},"page":"2543-2551","source":"Crossref","is-referenced-by-count":6,"title":["A previously undescribed de novo 4p15 deletion in a patient with apparently isolated metopic craniosynostosis"],"prefix":"10.1002","volume":"155","author":[{"given":"Viola","family":"Alesi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Barrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Morara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daria","family":"Darelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia","family":"Petrilli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Capalbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Pacella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Haass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Finocchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Novelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Bertoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,9]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"5","article-title":"Case report: Cytogenetic and molecular analysis of proximal interstitial deletion of 4p, review of the literature and comparison with Wolf\u2010Hirschhorn syndrome","volume":"36","author":"Bailey NG","year":"2010","journal-title":"J Assoc Genet Technol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32092"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20601"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320550203"},{"key":"e_1_2_7_6_1","first-page":"5","article-title":"Genetics of craniosynostosis: Review of the literature","volume":"2","author":"Ciurea AV","year":"2009","journal-title":"J Med Life"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31368"},{"key":"e_1_2_7_8_1","volume-title":"Craniosynostosis: Diagnosis, evaluation, and management","author":"Cohen MM","year":"2000"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-8-458"},{"key":"e_1_2_7_10_1","first-page":"92","article-title":"Interstitial deletion of the band 4p15.3 defined by sequential replication banding","volume":"33","author":"Davies J","year":"1990","journal-title":"Ann Genet"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/BC20040103"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0197-42"},{"key":"e_1_2_7_13_1","first-page":"35","volume-title":"Craniosynostosis: Diagnosis, evaluation and management","author":"Enlow DH","year":"2000"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320570413"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)80642-2"},{"key":"e_1_2_7_16_1","first-page":"59","article-title":"Interstitial deletion of the short arm of chromosome 4. 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