{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:15:31Z","timestamp":1773789331004,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T00:00:00Z","timestamp":1321833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Eurocat registry Northern Netherlands (NNL) has been used in regional context, as well as in national\/international context, to describe the epidemiology of oral clefts (OC). However, the region NNL seems to have prevalence data different from Dutch national registries and certain other European areas. This may be due to differences in registration methods or geographical variation. To investigate whether the prevalence of OC live births varies regionally in the Netherlands, we established time trends for NNL and the rest of the Netherlands over 1997\u20132007 using data from two national registries (the OC Registry and The Netherlands Perinatal Registry) and a regional registry (Eurocat NNL). We found that the overall live\u2010birth prevalence\u2014comprising cleft lip\/alveolus\u2009\u00b1\u2009cleft palate and cleft palate only\u2014was significantly higher in NNL (15.1\u201321.4 per 10,000) than in the rest of the Netherlands (13.2\u201316.1 per 10,000). None of the registries showed significant trends for NNL, whereas both national registries showed that the live\u2010birth prevalence of cleft lip\/alveolus\u2009\u00b1\u2009cleft palate decreased significantly in the rest of the Netherlands. Despite some differences in prevalence between the registries, they showed similar regional variation in prevalence and trends. In conclusion, the prevalence of OC live births varies significantly in the Netherlands, not only between but also within registries. This underlines that extrapolation of regional cleft data should be done with caution. To further investigate OC etiology and evaluate preventive strategies, future studies should consider geographical differences\u2014between and within countries\u2014regarding the various cleft sub\u2010phenotypes among live births, stillbirths, and pregnancy terminations. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.34343","type":"journal-article","created":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T19:23:10Z","timestamp":1321903390000},"page":"66-74","source":"Crossref","is-referenced-by-count":21,"title":["Regional variation in prevalence of oral cleft live births in the Netherlands 1997\u20132007: Time\u2010trend analysis of data from three Dutch registries"],"prefix":"10.1002","volume":"158A","author":[{"given":"Anna M.","family":"Rozendaal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashna D.","family":"Mohangoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin M.","family":"Ongkosuwito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone E.","family":"Buitendijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian K.","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christl","family":"Vermeij\u2010Keers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"41","volume-title":"[Congenital anomalies in the Netherlands 1996\u20102003 : Based on the National Obstetric and Neonatal Registries]","author":"Anthony S","year":"2005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2005.00632.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq226"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1597\/02-074.1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31447"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-5182(05)80389-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.02.008"},{"key":"e_1_2_7_9_1","first-page":"CD007950","article-title":"Effects and safety of periconceptional folate supplementation for preventing birth defects","volume":"10","author":"De\u2010Regil LM","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-007-0446-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2004.062810"},{"key":"e_1_2_7_12_1","unstructured":"Dutch Health Care Inspectorate.2009. 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