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Several examples of <jats:italic>twin spotting<\/jats:italic> have been described in humans including nevus vascularis mixtus, cutis tricolor, lesions of overgrowth, and deficient growth in Proteus and Elattoproteus syndromes, epidermolytic hyperkeratosis of Brocq, and the so\u2010called phacomatoses pigmentovascularis and pigmentokeratotica. We report on a 28\u2010year\u2010old man and a 15\u2010year\u2010old girl, who presented with a previously unrecognized association of paired cutaneous vascular nevi of the telangiectaticus and anemicus types (<jats:italic>naevus vascularis mixtus<\/jats:italic>) distributed in a mosaic pattern on the face (in both patients) and over the entire body (in the man) and a complex brain malformation (in both patients) consisting of cerebral hemiatrophy, hypoplasia of the cerebral vessels and homolateral hypertrophy of the skull and sinuses (known as Dyke\u2013Davidoff\u2013Masson malformation). Both patients had facial asymmetry and the young man had facial dysmorphism, seizures with EEG anomalies, hemiplegia, insulin\u2010dependent diabetes mellitus (IDDM), autoimmune thyroiditis, a large hepatic cavernous vascular malformation, and left Legg\u2010Calv\u00e9\u2010Perthes disease (LCPD) [LCPD\u2010like presentation]. Array\u2010CGH analysis and mutation analysis of the <jats:italic>RASA1<\/jats:italic> gene were normal in both patients. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.35221","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T18:51:06Z","timestamp":1347994266000},"page":"2870-2880","source":"Crossref","is-referenced-by-count":48,"title":["Nevus vascularis mixtus (cutaneous vascular twin nevi) associated with intracranial vascular malformation of the Dyke\u2013Davidoff\u2013Masson type in two patients"],"prefix":"10.1002","volume":"158A","author":[{"given":"Martino","family":"Ruggieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Milone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Pavone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Falsaperla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Polizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Caltabiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Fichera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Lia","family":"Gabriele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Distefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"De Pasquale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Salpietro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Micali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Pavone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2007.02299.x"},{"key":"e_1_2_6_3_1","first-page":"343","article-title":"Familial cutis tricolor: A possible example of paradominant inheritance","volume":"13","author":"Baba M","year":"2003","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2010.04.011"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-211-69500-5_22"},{"key":"e_1_2_6_6_1","first-page":"394","article-title":"Sturge\u2010Weber syndrome and accompanying Dyke\u2013Davidoff\u2013Masson syndromeCutis tricolor coexistent with cutis marmorata telangiectatica congenita: \u201cPhacomatosis achromico\u2010melano\u2010marmorata","volume":"18","author":"Boente Mdel C","year":"2008","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01470.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471227579"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.62.12.1928"},{"key":"e_1_2_6_10_1","first-page":"469","article-title":"What is your diagnosis? 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