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We report on a 26\u2010year\u2010old female with features of Noonan syndrome\u2013Multiple Lentigines and a heterozygous mutation: c.1517A\u2009&gt;\u2009C\u2013p.Gln506Pro in the <jats:italic>PTPN11<\/jats:italic> gene. The patient developed an unusual extensive lipomatosis and we discuss possible relationship between her lipomatosis and NS. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.35329","type":"journal-article","created":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T21:28:36Z","timestamp":1335216516000},"page":"1406-1410","source":"Crossref","is-referenced-by-count":1,"title":["Extensive abdominal lipomatosis in a patient with Noonan\/LEOPARD syndrome (Noonan syndrome\u2013Multiple Lentigines)"],"prefix":"10.1002","volume":"158A","author":[{"given":"Juliette","family":"Piard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Verloes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Cav\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Peuchmaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selim","family":"Bennaceur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Leheup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,23]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-010-0886-8"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.44"},{"key":"e_1_2_4_4_1","first-page":"265","article-title":"Multiple lipomas of the colon. 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