{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:48:40Z","timestamp":1790858920028,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T00:00:00Z","timestamp":1339977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Growth faltering occurs frequently in infancy in the 22q11 Deletion syndrome (22q11 DS). The subsequent course of growth in childhood and outcome for final adult height lacks consensus. We analyzed 5,149 growth data points from 812 Caucasian subjects with 22q11 DS, from neonates to 37 years old. Charts were constructed for height, weight, body mass index, and head circumference (OFC) using the LMS Chart Maker program. These charts were compared with the WHO birth to 4 years growth standard and US CDC 2000 growth reference between 5 and 20 years. Starting from the 50th centile at birth, by 6\u20139 months of age boys mean height and weight had fallen to the 9th centile, as did girls height but their weight fell less markedly, to the 25th centile. Feeding difficulties were non\u2010contributory. In children under 2 years old with congenital heart disease (CHD) mean weight was \u22120.5\u2009SD lighter than no CHD. Catch up growth occurred, more rapid in weight than height in boys. Up to 10 years old both sexes tracked between the 9th and 25th centiles. In adolescence, the trend was to overweight rather than obesity. At 19 years mean height was \u22120.72\u2009SD for boys, \u22120.89\u2009SD girls. OFC was significantly smaller than the WHO standard in infancy, between the 9th and 25th centile, rising to the 25th centile by 5 years old. Thereafter the mean was close to the 9th centile of the OFC UK growth reference, more prolonged and marked than in previous studies. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.35426","type":"journal-article","created":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T16:27:20Z","timestamp":1340036840000},"page":"2665-2671","source":"Crossref","is-referenced-by-count":34,"title":["Syndrome\u2010specific growth charts for 22q11.2 deletion syndrome in Caucasian children"],"prefix":"10.1002","volume":"158A","author":[{"given":"Alex","family":"Habel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Michael\u2010John","family":"McGinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine H.","family":"Zackai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Unanue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"McDonald\u2010McGinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogbrainres.2005.09.013"},{"key":"e_1_2_7_3_1","first-page":"332","article-title":"International 22q11.2. Deletion Syndrome Consortium. 2011. Practical guidelines for managing patients with 22q11.2 deletion syndrome","volume":"159","author":"Bassett AS","journal-title":"J Pediatr"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30984"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.1.101"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl066"},{"key":"e_1_2_7_7_1","unstructured":"Centers for Disease Control and Prevention.2000.CDC Growth Charts: United States. Centers for Disease Control and Prevention [website]. Available at:www.cdc.gov\/growthcharts"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012156651-7\/50019-8"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39238.399444.55"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.64.10.1478"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.1.144"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125817-200101000-00007"},{"key":"e_1_2_7_13_1","first-page":"58","article-title":"Is complete catch\u2010up possible for stunted malnourished children?","volume":"48","author":"Golden MMN","year":"1994","journal-title":"Eur J Clin Nutr"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/152.2.125"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30746"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.2012"},{"key":"e_1_2_7_17_1","unstructured":"PanH ColeTJ.2007.LMS Chartmaker 2.4. Medical Research Council.www.healthcareforallchildren.co.uk\/"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(63)80035-9"},{"key":"e_1_2_7_19_1","unstructured":"Royal College of Paediatrics and Child Health.2007.Application of WHO growth standards in the UK. Report prepared by the Joint SACN\/RCPC Expert Group on Growth Standards.www.sacn.gov.uk\/\u2026\/sacn.rcpch_who_growth_standards_report_final"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.34.10.798"},{"key":"e_1_2_7_21_1","first-page":"238","volume-title":"Velo\u2010cardio\u2010facial syndrome","author":"Shprintzen R","year":"2008"},{"key":"e_1_2_7_22_1","volume-title":"Gastrointestinal inflammation in children with Di George Syndrome","author":"Tomar R","year":"2010"},{"key":"e_1_2_7_23_1","first-page":"1","volume-title":"Linear growth retardation in less developed countries","author":"Waterlow JC","year":"1988"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.5.929"},{"key":"e_1_2_7_25_1","unstructured":"WHO.2006.Growth Standards for weight length\/height and BMI centiles (boys and girls)http:\/\/www.who.int\/childgrowth\/standards\/en\/"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.200030"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.35426","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.35426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T23:23:30Z","timestamp":1694561010000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.35426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,18]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1002\/ajmg.a.35426"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.35426","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,18]]}}}