{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:35:22Z","timestamp":1780518922023,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,8,6]],"date-time":"2012-08-06T00:00:00Z","timestamp":1344211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chromosome 22q11 microdeletion syndrome has a wide range of clinical manifestations including congenital heart malformations, palatal defects, endocrine abnormalities, immunologic deficits, learning difficulties, and an increased predisposition to psychiatric disease. Short stature and poor weight gain in infancy are common findings and are usually seen in the absence of hormone deficiencies. An increased frequency of obesity has been observed in adolescents and adults. We generated gender\u2010specific growth curves from 0 to 24 months of age, based on 479 length and 475 weight measurements from 138 Chilean patients with 22q11 deletion. Final adult height and weight on 25 individuals were analyzed. The 10th, 50th, and 90th centile\u2010smoothed curves for infants were built using the LMS method and compared with World Health Organization Child Growth Standards. The 50th centile for length in the deleted patients was slightly lower than the 10th centile of WHO standards in boys and girls. The same was observed for weight, although a trend toward a gradual increase near 2 years of age was observed, particularly in boys. Average adult height was 152\u2009cm (ranging from 143 to 162\u2009cm) in females, corresponding to the 10th centiles of WHO standards, and 166\u2009cm for males (160\u2013172\u2009cm), at the 20th centile of WHO standards. A third of the adult females and none of the males had body mass index (BMI) greater than 25. The curves should be useful to monitor growth in infants with 22q11 microdeletion syndrome. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.35525","type":"journal-article","created":{"date-parts":[[2012,8,6]],"date-time":"2012-08-06T20:11:49Z","timestamp":1344283909000},"page":"2682-2686","source":"Crossref","is-referenced-by-count":10,"title":["Growth in Chilean infants with chromosome 22q11 microdeletion syndrome"],"prefix":"10.1002","volume":"158A","author":[{"given":"Maria Luisa","family":"Guzman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Lay\u2010Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Willans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alonso","family":"Puga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela M.","family":"Repetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.02.039"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.2517-6161.1964.tb00553.x","article-title":"An analysis of transformations","volume":"26","author":"Box GEP","year":"1964","journal-title":"J Royal Statist Soc"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-2736"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780111005"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-010-1302-8"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125817-200101000-00007"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320450307"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.28.9.596"},{"key":"e_1_2_5_10_1","first-page":"11","article-title":"The Philadelphia story: The 22q11.2 deletion: Report on 250 patients","volume":"10","author":"McDonald\u2010McGinn DM","year":"1999","journal-title":"Genet Couns"},{"key":"e_1_2_5_11_1","unstructured":"Ministerio de Salud de Chile.2007.Referencia OMS para la evaluaci\u00f3n antropom\u00e9trica.http:\/\/www.redsalud.gov.cl\/archivos\/alimentosynutricion\/estrategiaintervencion\/antropometricoNINOS.pdf"},{"key":"e_1_2_5_12_1","unstructured":"Ministerio de Salud de Chile P. Universidad Cat\u00f3lica de Chile Universidad Alberto Hurtado.2011.Encuesta Nacional de Salud (ENS) Chile 2009\u20132010.http:\/\/www.redsalud.gov.cl\/portal\/url\/item\/99c12b89738d80d5e04001011e0113f8.pdf"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2009.01234.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471695998.mgs051"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.2"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.67.2.167"},{"key":"e_1_2_5_17_1","first-page":"227","volume-title":"Velo\u2010cardio\u2010facial syndrome","author":"Shprintzen RJ","year":"2008"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.87.2.104"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125817-200101000-00005"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.5.929"},{"key":"e_1_2_5_21_1","unstructured":"World Health Organization (WHO). The WHO Child Growth Standards.2006.http:\/\/www.who.int\/childgrowth\/en\/"},{"key":"e_1_2_5_22_1","volume-title":"WHO Child Growth Standards: Growth velocity based on weight, length and head circumference: Methods and development","author":"WHO Multicentre Growth Reference Study Group","year":"2009"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.35525","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.35525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T06:27:51Z","timestamp":1714285671000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.35525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,6]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1002\/ajmg.a.35525"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.35525","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,6]]}}}