{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:15:37Z","timestamp":1790144137088,"version":"4.0.1"},"reference-count":61,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T00:00:00Z","timestamp":1345161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The relative risk of immune\u2010mediated disorders (IMDs) among women carriers of premutation alleles is estimated by a survey for IMDs among 344 carrier women (age 19\u201381 years; mean 46.35 and SD 12.60) and 72 controls (age 18\u201387 years; mean 52.40 and SD 15.40). One hundred fifty four (44.77%) women carrier had at least one IMD, as did 20 controls (27.78%). Among women carriers, autoimmune thyroid disorder was the most common (24.4%), then fibromyalgia (10.2%), irritable bowel syndrome (IBS; 9.9%), Raynaud's phenomenon (7.6%), rheumatoid arthritis (RA; 3.8%), Sj\u00f6gren syndrome (2.6%), systemic lupus erythematosus (SLE; 2.03%), multiple sclerosis (1.74%). Of 55 carriers age 40 or older with FXTAS, 72.73% had at least one IMD, compared to 46.54% of those without FXTAS (n\u2009=\u2009159), and 31.58% of controls (n\u2009=\u200957). The estimated odds ratio (OR) for IMD is 2.6 (95% CI 1.2\u20135.6,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.015) for women with FXTAS relative to those without FXTAS; the likelihood of IMD in carriers without or with FXTAS was also significantly higher than for controls (OR 2.1, 95% CI 1.1\u20134.2,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.034; OR 5.5, 95% CI 2.4\u201312.5,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001, respectively). Similarly, the odds of having an IMD among carriers with FXPOI is about 2.4 times higher when compared to carriers without FXPOI (95% CI 1.1\u20135.0;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.021). The likelihood of IMD in carriers with or without FXPOI is greater (OR 2.4, 95% CI 1.1\u20135.0;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.021) compared to that of controls. \u00a9 2012 Wiley Periodicals, Inc.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.a.35569","type":"journal-article","created":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T17:32:04Z","timestamp":1345224724000},"page":"2473-2481","source":"Crossref","is-referenced-by-count":88,"title":["Immune\u2010mediated disorders among women carriers of fragile X premutation alleles"],"prefix":"10.1002","volume":"158A","author":[{"given":"Tri Indah","family":"Winarni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weerasak","family":"Chonchaiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanjung 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