{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T09:42:18Z","timestamp":1789897338593,"version":"4.0.1"},"reference-count":65,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T00:00:00Z","timestamp":1363046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Craniofacial and neural tissues develop in concert throughout prenatal and postnatal growth. FGFR\u2010related craniosynostosis syndromes, such as Apert syndrome (AS), are associated with specific phenotypes involving both the skull and the brain. We analyzed the effects of the FGFR P253R mutation for AS using the <jats:italic>Fgfr2<\/jats:italic><jats:sup><jats:italic>+\/P253R<\/jats:italic><\/jats:sup> Apert syndrome mouse to evaluate the effects of this mutation on these two tissues over the course of development from day of birth (P0) to postnatal day 2 (P2). Three\u2010dimensional magnetic resonance microscopy and computed tomography images were acquired from <jats:italic>Fgfr2<\/jats:italic><jats:sup><jats:italic>+\/P253R<\/jats:italic><\/jats:sup> mice and unaffected littermates at P0 (N\u2009=\u200928) and P2 (N\u2009=\u200920).Three\u2010dimensional coordinate data for 23 skull and 15 brain landmarks were statistically compared between groups. Results demonstrate that the <jats:italic>Fgfr2<\/jats:italic><jats:sup><jats:italic>+\/P253R<\/jats:italic><\/jats:sup> mice show reduced growth in the facial skeleton and the cerebrum, while the height and width of the neurocranium and caudal regions of the brain show increased growth relative to unaffected littermates. This localized correspondence of differential growth patterns in skull and brain point to their continued interaction through development and suggest that both tissues display divergent postnatal growth patterns relative to unaffected littermates. However, the change in the skull\u2013brain relationship from P0 to P2 implies that each tissue affected by the mutation retains a degree of independence, rather than one tissue directing the development of the other. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.a.35805","type":"journal-article","created":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T02:59:37Z","timestamp":1363229977000},"page":"745-757","source":"Crossref","is-referenced-by-count":28,"title":["Postnatal brain and skull growth in an Apert syndrome mouse model"],"prefix":"10.1002","volume":"161","author":[{"given":"Cheryl A.","family":"Hill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neus","family":"Mart\u00ednez\u2010Abad\u00edas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan 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