{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:09:43Z","timestamp":1790456983703,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T00:00:00Z","timestamp":1375401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Ehlers\u2013Danlos Syndrome hypermobility type (EDS\u2013HT) and joint hypermobility syndrome (JHS) are two overlapping heritable connective tissue disorders. Patients with these conditions have many and various complaints; limitations in performing daily activities, reduced muscle strength and proprioception, kinesiophobia, and pain. There is a lack of evidence\u2010based treatment approaches; a few studies have shown effect of physiotherapy. Many authors propose multidisciplinary treatment, but this has neither been described nor evaluated for this patient group. The aim of this pilot study was to investigate if a multidisciplinary rehabilitation program combining physical and cognitive\u2010behavioral therapy was feasible, safe and effective for 12 women with EDS\u2013HT\/JHS. Intervention was offered as a group program and consisted of three parts: (1) Two and a half week in a rehabilitation unit with testing, physical training, group discussions and lectures. (2) Individual home exercises for three months with weekly guidance by local physiotherapist. (3) Readmission four days for retesting and further training advice. All participants completed the intervention. We found significant changes in perceived performance of daily activities, significant increase of muscle strength and endurance and a significant reduction of kinesiophobia. There were smaller changes in self\u2010perceived pain. The participants also reported increased participation in daily life. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.36060","type":"journal-article","created":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T18:52:43Z","timestamp":1375469563000},"page":"3005-3011","source":"Crossref","is-referenced-by-count":76,"title":["Multidisciplinary treatment of disability in ehlers\u2013danlos syndrome hypermobility type\/hypermobility syndrome: A pilot study using a combination of physical and cognitive\u2010behavioral therapy on 12 women"],"prefix":"10.1002","volume":"161","author":[{"given":"Trine","family":"Bathen","sequence":"first","affiliation":[{"name":"TRS National Resource Centre for Rare Disorders Sunnaas Rehabilitation Hospital HF Nesodden Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anett Bj\u00f8rn\u00f8deg\u00e5rd","family":"H\u00e5ngmann","sequence":"additional","affiliation":[{"name":"Clinic for Neuro\u2010Rehabilitation Sunnaas Rehabilitation Hospital HF Askim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Hoff","sequence":"additional","affiliation":[{"name":"TRS National Resource Centre for Rare Disorders Sunnaas Rehabilitation Hospital HF Nesodden Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liv \u00d8in\u00e6s","family":"Andersen","sequence":"additional","affiliation":[{"name":"TRS National Resource Centre for Rare Disorders Sunnaas Rehabilitation Hospital HF Nesodden Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svend","family":"Rand\u2010Hendriksen","sequence":"additional","affiliation":[{"name":"TRS National Resource Centre for Rare Disorders Sunnaas Rehabilitation Hospital HF Nesodden Norway"},{"name":"University of Oslo, Institute of Medicine Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2012.03.024"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980428)77:1<31::AID-AJMG8>3.0.CO;2-O"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen103"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.06.009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14038190410017542"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000841740407100406"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33231"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33585"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35483"},{"key":"e_1_2_8_11_1","first-page":"998","article-title":"Symptom and joint mobility progression in the joint hypermobility syndrome (Ehlers\u2013Danlos syndrome, hypermobility type)","volume":"29","author":"Castori M","year":"2011","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2044-2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2012.01858.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20582"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-009-0070-5"},{"key":"e_1_2_8_16_1","first-page":"1777","article-title":"The revised (Brighton, 1998) criteria for the diagnosis of benign joint hypermobility syndrome (BJHS)","volume":"27","author":"Grahame R","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2003.08.001"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31817c6c4b"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24276"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20070119"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem290"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328342d3af"},{"key":"e_1_2_8_23_1","first-page":"176","volume-title":"Hypermobility syndrome. 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