{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:14:42Z","timestamp":1792167282059,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T00:00:00Z","timestamp":1375660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Smith\u2013Lemli\u2013Opitz syndrome (SLOS) is a neurodevelopmental disorder caused by inborn errors of cholesterol metabolism resulting from mutations in 7\u2010dehydrocholesterol reductase (<jats:italic>DHCR7<\/jats:italic>). There are only a few studies describing the brain imaging findings in SLOS. This study examines the prevalence of magnetic resonance imaging (MRI) abnormalities in the largest cohort of patients with SLOS to date. Fifty\u2010five individuals with SLOS (27 M, 28 F) between age 0.17 years and 25.4 years (mean\u2009=\u20096.2, SD\u2009=\u20095.8) received a total of 173 brain MRI scans (mean\u2009=\u20093.1 per subject) on a 1.5T GE scanner between September 1998 and December 2003, or on a 3T Philips scanner between October 2010 and September 2012; all exams were performed at the Clinical Center of the National Institutes of Health. We performed a retrospective review of these imaging studies for both major and minor brain anomalies. Aberrant MRI findings were observed in 53 of 55 (96%) SLOS patients, with abnormalities of the septum pellucidum the most frequent (42\/55, 76%) finding. Abnormalities of the corpus callosum were found in 38 of 55 (69%) patients. Other findings included cerebral atrophy, cerebellar atrophy, colpocephaly, white matter lesions, arachnoid cysts, Dandy\u2013Walker variant, and type I Chiari malformation. Significant correlations were observed when comparing MRI findings with sterol levels and somatic malformations. Individuals with SLOS commonly have anomalies involving the midline and para\u2010midline structures of the brain. Further studies are required to examine the relationship between structural brain abnormalities and neurodevelopmental disability in SLOS. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.36096","type":"journal-article","created":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T20:02:45Z","timestamp":1375732965000},"page":"2407-2419","source":"Crossref","is-referenced-by-count":40,"title":["Brain magnetic resonance imaging findings in smith\u2013lemli\u2013opitz syndrome"],"prefix":"10.1002","volume":"161","author":[{"given":"Ryan W.Y.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neurology and Developmental Medicine Kennedy Krieger Institute Baltimore Maryland"},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra 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