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He was clinically diagnosed with cardio\u2010facio\u2010cutaneous (CFC) syndrome, and was confirmed to have a germline V\u2010raf murine sarcoma viral oncogene homologue B1 (<jats:italic>BRAF<\/jats:italic>) c.721 A&gt;C mutation. At 1 month of age, he presented with a transient myelodysplastic\/myeloproliferative neoplasm (MDS\/MPN), which improved within a month without the administration of antineoplastic agents. This is the first report of CFC syndrome with MDS\/MPN. 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