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This rare condition, affecting 1 in 8,500\u201325,000 newborns, is extremely complex because of its variability in clinical presentation, irregularities in its inheritance pattern, and the heterogeneity of molecular genetic alterations that can be found in affected individuals. Both syndromal and nonsyndromal forms are reviewed and the major molecular genetic alterations thus far reported in association with SHFM are discussed. This updated overview should be helpful for clinicians in their efforts to make an appropriate clinical and genetic diagnosis, provide an accurate recurrence risk assessment, and formulate a management plan. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajmg.a.36239","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T17:49:33Z","timestamp":1381513773000},"page":"2860-2872","source":"Crossref","is-referenced-by-count":58,"title":["Clinical, genetic, and molecular aspects of split\u2010hand\/foot malformation: An update"],"prefix":"10.1002","volume":"161","author":[{"given":"Fiorella","family":"Gurrieri","sequence":"first","affiliation":[{"name":"Istituto di Genetica Medica Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Everman","sequence":"additional","affiliation":[{"name":"Greenwood Genetic Center Greenwood 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