{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:51:05Z","timestamp":1790419865793,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T00:00:00Z","timestamp":1386201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:label\/><jats:p>Agenesis or isolated hypodontia of the maxillary permanent canines is a very rare dental anomaly. We report on nine unrelated Thai patients with this condition. Three of them had one affected parent. Three heterozygous missense mutations (p.Arg171Cys; p.Gly213Ser; and IVS2+1G&gt;A) were identified in <jats:italic>WNT10A<\/jats:italic> in six patients. The p.Gly213Cys mutation was found in four patients. One of the patients who had p.Gly213Ser mutation also had peg\u2010shaped (microdontia of the) maxillary lateral incisors with dens invaginatus. The mothers of two patients who carried the same mutation as their affected sons (p.Gly213Ser and p.Arg171Cys) had microdontia of the maxillary permanent lateral incisor. Our study has demonstrated for the first time that agenesis of the maxillary permanent canines is a distinct entity, associated with mutations in <jats:italic>WNT10A<\/jats:italic>. Inheritance appears to be autosomal dominant. Agenesis of the maxillary permanent canines may accompany by microdontia of the maxillary permanent lateral incisors and dens invaginatus of the maxillary permanent lateral incisors. Mutations could not be identified in the coding exons of <jats:italic>WNT10A<\/jats:italic> in three patients. They might be located outside the coding exons, including the promoter regions. However, it is likely that agenesis of the maxillary permanent canines is a heterogeneous disorder. \u00a9 2013 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.36280","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T20:16:39Z","timestamp":1386274599000},"page":"360-363","source":"Crossref","is-referenced-by-count":31,"title":["<i>WNT<\/i><i>10<\/i><i>A<\/i> mutations also associated with agenesis of the maxillary permanent canines, a separate entity"],"prefix":"10.1002","volume":"164","author":[{"given":"P.","family":"Kantaputra","sequence":"first","affiliation":[{"name":"Division of Pediatric Dentistry Department of Orthodontics and Pediatric Dentistry Faculty of Dentistry Chiang Mai University Chiang Mai Thailand"},{"name":"Craniofacial Genetics Laboratory Faculty of Dentistry Chiang Mai University Chiang Mai Thailand"},{"name":"Dentaland Clinic Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kaewgahya","sequence":"additional","affiliation":[{"name":"Craniofacial Genetics Laboratory Faculty of Dentistry Chiang Mai University Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Kantaputra","sequence":"additional","affiliation":[{"name":"Craniofacial Genetics Laboratory Faculty of Dentistry Chiang Mai University Chiang Mai Thailand"},{"name":"Dentaland Clinic Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/520064"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2345(1996)39:2<87::AID-AJP1>3.0.CO;2-N"},{"key":"e_1_2_6_4_1","first-page":"382","article-title":"A congenitally missing canine in association with other dental disturbances: Report of two cases","volume":"50","author":"Bazan MT","year":"1983","journal-title":"ASDC J Dent Child"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.06.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2004.00571.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21384"},{"key":"e_1_2_6_8_1","first-page":"5","article-title":"Absent canines","volume":"46","author":"Dolamore WH","year":"1925","journal-title":"Br Dent J"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2011.542539"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/oxfordjournals.jhered.a104213","article-title":"Two independent inherited tooth anomalies in one family","volume":"27","author":"Gruneberg H","year":"1936","journal-title":"J Hered"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1597\/10-208"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33840"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510391052"},{"key":"e_1_2_6_14_1","first-page":"364","article-title":"Absence of maxillary canines. 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