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Postnatal chromosome analysis revealed an unbalanced karyotype involving a der (5) and array\u2010CGH defined two unbalanced regions with partial 2.3\u2009Mb deletion of 5q35.3 in combination with a large 19.5\u2009Mb duplication of chromosome 10 from q25.3 to q26.3. Parental karyotyping analysis showed that the father was carrier of a balanced t(5;10)(q35;q25). Two cousins of the proband with similar facial features had the same unbalanced karyotype with presence of the der (5) inherited from the malsegregation of the familial translocation. Additionally, three siblings (two deceased and one abortion) manifested a more severe phenotype including congenital heart defect, cleft palate, and agenesis of the corpus callosum and were diagnosed with unbalanced karyotypes inherited from the familial balanced translocation. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.36412","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T21:24:33Z","timestamp":1391030673000},"page":"1254-1261","source":"Crossref","is-referenced-by-count":4,"title":["Microarray delineation of familial chromosomal imbalance with deletion 5q35 and duplication 10q25 in a child showing multiple anomalies and dysmorphism"],"prefix":"10.1002","volume":"164","author":[{"given":"Amira","family":"Masri","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Jordan Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Gimelli","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine and Laboratories Geneva University Hospitals Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan","family":"Hamamy","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine and Development Geneva University Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Sloan\u2010B\u00e9na","sequence":"additional","affiliation":[{"name":"Department of Genetic Medicine and Laboratories Geneva University Hospitals Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,29]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"199","article-title":"Partial trisomy of the distal part of 10q: A report of two Egyptian cases","volume":"19","author":"Aglan MS","year":"2008","journal-title":"Genet Couns"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31087"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31053"},{"key":"e_1_2_6_5_1","unstructured":"Decipher.2012. 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