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It is likely that most of those individuals have an AS\u2010like syndrome that is clinically and molecularly distinct from AS. These AS\u2010like syndromes can be broadly classified into chromosomal microdeletion and microduplication syndromes, and single\u2010gene disorders. The microdeletion\/microduplication syndromes are now easily identified by chromosomal microarray analysis and include Phelan\u2013McDermid syndrome (chromosome 22q13.3 deletion), <jats:italic>MBD5<\/jats:italic> haploinsufficiency syndrome (chromosome 2q23.1 deletion), and <jats:italic>KANSL1<\/jats:italic> haploinsufficiency syndrome (chromosome 17q21.31 deletion). The single\u2010gene disorders include Pitt\u2013Hopkins syndrome (<jats:italic>TCF4<\/jats:italic>), Christianson syndrome (<jats:italic>SLC9A6<\/jats:italic>), Mowat\u2013Wilson syndrome (<jats:italic>ZEB2<\/jats:italic>), Kleefstra syndrome (<jats:italic>EHMT1<\/jats:italic>), and Rett (<jats:italic>MECP2<\/jats:italic>) syndrome. They also include disorders due to mutations in <jats:italic>HERC2<\/jats:italic>, adenylosuccinase lyase (<jats:italic>ADSL<\/jats:italic>), <jats:italic>CDKL5<\/jats:italic>, <jats:italic>FOXG1<\/jats:italic>, <jats:italic>MECP2<\/jats:italic> (duplications), <jats:italic>MEF2C<\/jats:italic>, and <jats:italic>ATRX<\/jats:italic>. Although many of these single\u2010gene disorders can be caused by chromosomal microdeletions resulting in haploinsufficiency of the critical gene, the individual disorders are often caused by intragenic mutations that cannot be detected by chromosomal microarray analysis. We provide an overview of the clinical features of these syndromes, comparing and contrasting them with AS, in the hope that it will help guide clinicians in the diagnostic work\u2010up of individuals with AS\u2010like syndromes. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.36416","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T21:25:12Z","timestamp":1391030712000},"page":"975-992","source":"Crossref","is-referenced-by-count":89,"title":["If not Angelman, what is it? a review of Angelman\u2010like syndromes"],"prefix":"10.1002","volume":"164","author":[{"given":"Wen\u2010Hann","family":"Tan","sequence":"first","affiliation":[{"name":"NIH Rare Diseases Clinical Research Network\u2014Angelman, Rett, &amp; Prader\u2010Willi Syndromes Consortium Birmingham Alabama"},{"name":"Division of Genetics Boston Children's Hospital; Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne M.","family":"Bird","sequence":"additional","affiliation":[{"name":"NIH Rare Diseases Clinical Research Network\u2014Angelman, Rett, &amp; Prader\u2010Willi Syndromes Consortium Birmingham Alabama"},{"name":"Department of Pediatrics University of California San Diego California"},{"name":"Division of Genetics\/Dysmorphology Rady Children's Hospital San Diego San Diego California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald L.","family":"Thibert","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital; Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Williams","sequence":"additional","affiliation":[{"name":"Raymond C. 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