{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:10:09Z","timestamp":1761919809111,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T00:00:00Z","timestamp":1394409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>Jacobsen syndrome (11q\u2010) is a rare chromosomal disorder caused by deletions in distal11q. Many of the most common and severe congenital heart defects that occur in the general population occur in 11q\u2010. Previous studies have demonstrated that gene\u2010targeted deletion in mice of ETS\u20101, a cardiac transcription factor in distal 11q, causes ventricular septal defects with 100% penetrance. It is unclear whether deletion of other genes in distal 11q contributes to the full spectrum of congenital heart defects that occur in 11q\u2010. Three patients with congenital heart defects have been identified that carry a translocation or paracentric inversion with a breakpoint in distal 11q disrupting one of two functionally related genes, <jats:italic>OPCML<\/jats:italic> and <jats:italic>Neurotrimin<\/jats:italic>. OPCML and Neurotrimin are two members of the IgLON subfamily of cell adhesion molecules. In this study, we report the generation and cardiac phenotype of single and double heterozygous gene\u2010targeted <jats:italic>OPCML<\/jats:italic> and <jats:italic>Neurotrimin<\/jats:italic> knockout mice. No cardiac phenotype was detected, consistent with a single gene model as the cause of the congenital heart defects in 11q\u2010. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.36441","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T17:47:54Z","timestamp":1394473674000},"page":"966-974","source":"Crossref","is-referenced-by-count":8,"title":["Gene\u2010targeted deletion of <i>OPCML<\/i> and <i>Neurotrimin<\/i> in mice does not yield congenital heart defects"],"prefix":"10.1002","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0881-2305","authenticated-orcid":false,"given":"Maoqing","family":"Ye","sequence":"first","affiliation":[{"name":"Key Laboratory of Arrhythmia, Ministry of Education, East Hospital Tongji University School of Medicine Shanghai China"},{"name":"Department of Pediatrics UCSD School of Medicine San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabienne","family":"Parente","sequence":"additional","affiliation":[{"name":"Department of Medicine UCSD School of Medicine San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine UCSD School of Medicine San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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