{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T06:40:34Z","timestamp":1696660834818},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T00:00:00Z","timestamp":1396915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:label \/><jats:p>Waardenburg syndrome (WS) is a neurocristopathy characterized by pigmentation abnormalities of the skin, hair, and iris, as well as sensorineural hearing loss. Contiguous gene deletions encompassing <jats:italic>SOX10<\/jats:italic> are rare, which limits conclusions about genotype\u2013phenotype correlation regarding patient prognosis and management. This study adds to the existing body of knowledge by characterizing a 2.4\u2009Mb deletion [arr[hg19] 22q12.3\u2010q13.1 (36467502\u201338878207)x1] encompassing <jats:italic>SOX10<\/jats:italic> and 53 additional RefSeq genes in a 15\u2010year\u2010old female with atypical WS. The patient presented with developmental delay, profound bilateral sensorineural hearing loss, heterochromia iridis, hypotonia, and bilateral finger contractures. Published genomic and phenotypic profiles of patients with <jats:italic>SOX10<\/jats:italic>\u2010encompassing deletions point toward several plausible candidate gene that could account for the considerable clinical heterogeneity. These studies suggest the existence of modifiers among the co\u2010deleted, dosage\u2010sensitive genes (e.g., <jats:italic>MYH9<\/jats:italic>) and among genes whose effect may depend on the unmasking of recessive mutations (e.g., <jats:italic>PLA2G6<\/jats:italic>). Finally, we highlight evidence illustrating extensive interconnectivity of <jats:italic>SOX10<\/jats:italic>\u2010hypothesizing that haploinsufficiency of <jats:italic>SOX10<\/jats:italic> may \u201cunmask\u201d subtler effects on expression or epistasis associated with variants in <jats:italic>SOX10<\/jats:italic> targets (e.g., <jats:italic>DHH<\/jats:italic>), in its partners (e.g., <jats:italic>PAX3<\/jats:italic>, <jats:italic>EGR2<\/jats:italic>), and in genes with functional overlap (e.g., <jats:italic>SOX8<\/jats:italic>, <jats:italic>SOX9<\/jats:italic>). \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.36446","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T21:51:21Z","timestamp":1396993881000},"page":"1512-1519","source":"Crossref","is-referenced-by-count":15,"title":["Phenotypic variability in Waardenburg syndrome resulting from a 22q12.3\u2010q13.1 microdeletion involving <i>SOX10<\/i>"],"prefix":"10.1002","volume":"164","author":[{"given":"Brezo","family":"Jelena","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine David Geffen School of Medicine University of California Los Angeles UCLA Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lam","family":"Christina","sequence":"additional","affiliation":[{"name":"Department of Pediatrics David Geffen School of Medicine University of California Los Angeles UCLA Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilain","family":"Eric","sequence":"additional","affiliation":[{"name":"Department of Pediatrics David Geffen School of Medicine University of California Los Angeles UCLA Los Angeles California"},{"name":"Department of Human Genetics David Geffen School of Medicine University of California Los Angeles UCLA Los Angeles California"},{"name":"UCLA Clinical Genomics Center Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quintero\u2010Rivera","family":"Fabiola","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine David Geffen School of Medicine University of California Los Angeles UCLA Los Angeles California"},{"name":"UCLA Clinical Genomics Center Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.057836"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/522090"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.29"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2013.04.024"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21173"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh343"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01087"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.03.010"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/372525a0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32402"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10404"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.10.021"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e31822c79f9"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02477"},{"key":"e_1_2_8_16_1","first-page":"336","article-title":"Arch Klaus Stift","volume":"22","author":"Klein D","year":"1947","journal-title":"Vererb Forsch"},{"key":"e_1_2_8_17_1","unstructured":"LowensteinMK.2009. 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