{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T13:41:21Z","timestamp":1794318081511,"version":"4.9.0"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T00:00:00Z","timestamp":1397001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sophies Minde Foundation, Norway"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:label\/><jats:p>This study aims to investigate how fatigue affects adults with verified Marfan syndrome (MFS) in their daily lives, by examining fatigue levels and prevalence of severe fatigue compared to the general Norwegian population and individuals with other comparable chronic conditions. We investigated associations between socio\u2010demographic characteristics, Marfan\u2010related health problems, pain and fatigue. A cross\u2010sectional study was conducted, using a postal questionnaire including the Fatigue Severity Scale (FSS) and questions on socio\u2010demographic characteristics, Marfan\u2010related health problems and pain. One hundred seventeen persons with MFS were invited to participate, 73 answered (62%). Participants reported significantly higher FSS scores and prevalence of severe fatigue compared to the general Norwegian population and patients with rheumatoid arthritis (RA), but lower than for other chronic conditions. Participants with chronic pain reported higher fatigue scores than those without chronic pain. Participants on disability benefits reported higher fatigue scores than participants who were working or enrolled in higher education. Marfan\u2010related health problems like aortic dissection and use of blood pressure medication were not significantly associated with fatigue. In multivariable regression analyses chronic pain and employment status were significantly associated with fatigue. The final multivariable model explained 24% of the variance in fatigue scores. Our results show that fatigue is common in MFS patients and that it interferes with their daily lives. Chronic pain and employment status show significant associations to fatigue. This implies that fatigue is important to address when meeting MFS patients in clinical practice. There is need for more research on fatigue in Marfan syndrome. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.36574","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T20:59:20Z","timestamp":1397077160000},"page":"1931-1939","source":"Crossref","is-referenced-by-count":47,"title":["Fatigue in adults with Marfan syndrome, occurrence and associations to pain and other factors"],"prefix":"10.1002","volume":"164","author":[{"given":"Trine","family":"Bathen","sequence":"first","affiliation":[{"name":"TRS National Resource Centre for Rare Disorders Sunnaas Rehabilitation Hospital Nesoddtangen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gry","family":"Velvin","sequence":"additional","affiliation":[{"name":"TRS National Resource Centre for Rare Disorders Sunnaas Rehabilitation Hospital Nesoddtangen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svend","family":"Rand\u2010Hendriksen","sequence":"additional","affiliation":[{"name":"TRS National Resource Centre for Rare Disorders Sunnaas Rehabilitation Hospital Nesoddtangen Norway"},{"name":"Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde Stendal","family":"Robinson","sequence":"additional","affiliation":[{"name":"Institute of Health and Society Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.5.1151"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2012.06.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(01)00228-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-200202000-00006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/580460"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.5664\/jcsm.27490","article-title":"Fatigue, tiredness, and lack of energy improve with treatment for OSA","volume":"5","author":"Chotinaiwattarakul W","year":"2009","journal-title":"J Clin Sleep Med"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458509360040"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960424)62:4<417::AID-AJMG15>3.0.CO;2-R"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(03)00371-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-010-9769-3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000148589.87107.9C"},{"key":"e_1_2_7_13_1","first-page":"635","article-title":"Minimal clinically important difference for 7 measures of fatigue in patients with systemic lupus erythematosus","volume":"35","author":"Goligher EC","year":"2008","journal-title":"J Rheumatol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0434-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511432328"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.3.351"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.13.1389"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1989.00520460115022"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-6870(87)90010-X"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.20562"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14034940410028406"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.072785"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(97)00291-2"},{"key":"e_1_2_7_24_1","first-page":"1496","article-title":"Psychosocial variables and fatigue: A longitudinal study comparing individuals with rheumatoid arthritis and healthy controls","volume":"33","author":"Mancuso CA","year":"2006","journal-title":"J Rheumatol"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1191\/1352458505ms1198oa"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4637.2000.00022.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2006.04054.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.308.6931.763"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel450"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2001.600405.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2001.600406.x"},{"key":"e_1_2_7_32_1","volume-title":"Nursing research. 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