{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:19:42Z","timestamp":1791937182267,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T00:00:00Z","timestamp":1402876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["R01CA111355"],"award-info":[{"award-number":["R01CA111355"]}]},{"name":"NIH","award":["K05 CA157439"],"award-info":[{"award-number":["K05 CA157439"]}]},{"name":"NIH","award":["U10CA13539"],"award-info":[{"award-number":["U10CA13539"]}]},{"name":"NIH","award":["U10CA98543"],"award-info":[{"award-number":["U10CA98543"]}]},{"DOI":"10.13039\/100000885","name":"Children's Cancer Research Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000885","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Pedigree and Population Resource"},{"DOI":"10.13039\/100010637","name":"Huntsman Cancer Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010637","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Utah Population Database"},{"name":"National Cancer Institute's SEER Program"},{"DOI":"10.13039\/100006614","name":"Utah State Department of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006614","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007747","name":"University of Utah","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007747","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Beckwith\u2013Wiedemann Syndrome (BWS) and familial adenomatous polyposis (FAP) are known to predispose to hepatoblastoma (HB). A case\u2013control study was conducted through the Children's Oncology Group (COG) to study the association of HB with isolated congenital abnormalities. Cases (N\u2009=\u2009383) were diagnosed between 2000 and 2008. Controls (N\u2009=\u2009387) were recruited from state birth registries, frequency matched for sex, region, year of birth, and birth weight. Data on congenital abnormalities among subjects and covariates were obtained by maternal telephone interview. Odds ratios (OR) and 95% confidence intervals (CI) describing the association between congenital abnormalities with HB, adjusted for sex, birth weight, maternal age and maternal education, were calculated using unconditional logistic regression. There was a significant association of HB with kidney, bladder, or sex organ abnormalities (OR\u2009=\u20094.75; 95% CI: 1.74\u201313) which appeared to be specific to kidney\/bladder defects (OR\u2009=\u20094.3; 95% CI: 1.2\u201315.3) but not those of sex organs (OR\u2009=\u20091.24; 95% CI: 0.37\u20134.1). Elevated but non\u2010significant ORs were found for spina bifida or other spinal defects (OR\u2009=\u20092.12; 95% CI: 0.39\u201311.7), large or multiple birthmarks (OR\u2009=\u20091.33; 95% CI: 0.81\u20132.21). The results were validated through the Utah Population Database (UPDB), a statewide population\u2010based registry linking birth certificates, medical records, and cancer diagnoses. In the UPDB, there were 29 cases and 290 population controls matched 10:1 on sex and birth year. Consistent with the COG findings, kidney\/bladder defects were associated with hepatoblastoma. These results confirm the association of HB with kidney\/bladder abnormalities. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajmg.a.36638","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T21:39:38Z","timestamp":1402954778000},"page":"2250-2255","source":"Crossref","is-referenced-by-count":29,"title":["Congenital abnormalities and hepatoblastoma: A report from the Children's Oncology Group (COG) and the Utah Population Database (UPDB)"],"prefix":"10.1002","volume":"164","author":[{"given":"Rajkumar","family":"Venkatramani","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Children's Hospital Los Angeles Los Angeles California"},{"name":"Department of Pediatrics Keck School of Medicine University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan G.","family":"Spector","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Masonic Cancer Center University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Georgieff","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Masonic Cancer Center University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"University of Texas Health Sciences Center San Antonio San Antonio Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Krailo","sequence":"additional","affiliation":[{"name":"University of Southern California Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio","family":"Malogolowkin","sequence":"additional","affiliation":[{"name":"Children's Hospital of Wisconsin Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Kohlmann","sequence":"additional","affiliation":[{"name":"Department of Oncological Sciences Huntsman Cancer Institute Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Curtin","sequence":"additional","affiliation":[{"name":"Center for Children's Cancer Research (C3R) University of Utah Health Sciences Center Salt Lake City Utah"},{"name":"Department of Internal Medicine University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel K.","family":"Fonstad","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Masonic Cancer Center University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Schiffman","sequence":"additional","affiliation":[{"name":"Department of Oncological 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Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181a974c8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31819"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.10.024"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1874-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-2630"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069077"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24936"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1681\/ASN.V1191767","article-title":"Liver involvement in autosomal\u2010dominant polycystic kidney disease: Therapeutic dilemma","volume":"11","author":"Chauveau 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