{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:30:36Z","timestamp":1790753436674,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T00:00:00Z","timestamp":1404259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:label\/><jats:p>Rubinstein\u2013Taybi syndrome (RSTS) is an autosomal dominant disorder characterized by variable degrees of intellectual disability, an unusual face, distal limb anomalies including broad thumbs and broad halluces, a large group of variable other major and minor anomalies, and decreased somatic growth. The aim of the present study was to construct up\u2010to\u2010date growth charts specific for infants and children with RSTS. We collected retrospective growth data of 92 RSTS individuals of different ancestries. Data were corrected for secular trends and population of origin to the Dutch growth charts of 2009. On average, 17.9 measurements were available per individual. Height, weight and body mass index (BMI) references for males and females were constructed using the <jats:italic>lambda<\/jats:italic>, <jats:italic>mu<\/jats:italic>, <jats:italic>sigma<\/jats:italic> method. RSTS individuals had normal birth weight and length. Mean final heights were 162.6\u2009cm [\u22122.99 standard deviation score (SDS)] for males and 151.0\u2009cm [\u22123.01 SDS] for females. BMI SDS compared to the general Dutch population were \u22120.06 and 1.40 SDS for males and females, respectively. Head circumference SDS compared to the general Dutch population was \u22121.89 SDS for males and \u22122.71 SDS for females. This is the first study to publish growth charts using only molecularly proven RSTS individuals. These syndrome\u2010specific growth charts can be used in managing problems related to growth in RSTS individuals. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.36654","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T18:59:09Z","timestamp":1404327549000},"page":"2300-2309","source":"Crossref","is-referenced-by-count":31,"title":["Growth charts for individuals with Rubinstein\u2013Taybi syndrome"],"prefix":"10.1002","volume":"164","author":[{"given":"Lex","family":"Beets","sequence":"first","affiliation":[{"name":"Department of Pediatrics Emma's Children's Hospital\/Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Rodr\u00edguez\u2010Fonseca","sequence":"additional","affiliation":[{"name":"Spanish Rubinstein\u2010Taybi Association Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul C.","family":"Hennekam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Emma's Children's Hospital\/Academic Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,2]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"45","article-title":"The LMS method for constructing normalized growth standards","volume":"44","author":"Cole TJ","year":"1990","journal-title":"Eur J Clin Nutr"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780111005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03344156"},{"key":"e_1_2_6_5_1","first-page":"12","article-title":"Primaire en secundaire preventie van congenitale heupluxatie","volume":"17","author":"De Jonge G","year":"1986","journal-title":"Ned Tijdsch Geneeskd"},{"key":"e_1_2_6_6_1","first-page":"1","volume-title":"Growth diagrams for ages 1\u201325 years in The Netherlands","author":"de Wijn J","year":"1960"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.82.2.107"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200003000-00006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320370604"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201594"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320370613"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35519"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-8-8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.2012"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.1.45"},{"key":"e_1_2_6_16_1","first-page":"330","article-title":"The secular trend in The Netherlands. 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