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We report on the perinatal presentation of 10 patients with Noonan syndrome (NS), nine with Cardiofaciocutaneous syndrome (CFCS) and three with Costello syndrome (CS), in conjunction with the results of a comprehensive literature review. The majority of perinatal findings in NS, CS, and CFCS are shared: polyhydramnios; prematurity; lymphatic dysplasia; macrosomia; relative macrocephaly; respiratory distress; hypotonia, as well as cardiac and renal anomalies. In contrast, fetal arrhythmia and neonatal hypoglycemia are relatively specific to CS. NS, CS, and CFCS should all be considered as a possible diagnosis in pregnancies with a normal karyotype and ultrasound findings of a RASopathy. Recognition of the common perinatal findings of these disorders should facilitate both their prenatal and neonatal diagnosis. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.36737","type":"journal-article","created":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T20:53:23Z","timestamp":1411419203000},"page":"2814-2821","source":"Crossref","is-referenced-by-count":87,"title":["Perinatal features of the RASopathies: Noonan syndrome, Cardiofaciocutaneous syndrome and Costello syndrome"],"prefix":"10.1002","volume":"164","author":[{"given":"Angela","family":"Myers","sequence":"first","affiliation":[{"name":"Division of Medical Genetics Department of Pediatrics Stanford University Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan A.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics Department of Pediatrics Stanford University Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Luise","family":"Brennan","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics Department of Pediatrics Stanford University Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Curry","sequence":"additional","affiliation":[{"name":"Genetic Medicine Central California Fresno California"},{"name":"Department of Pediatrics University of California San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward D.","family":"Esplin","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics Department of Pediatrics Stanford University Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie","family":"Fisher","sequence":"additional","affiliation":[{"name":"Genetic Medicine Central California Fresno California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Homeyer","sequence":"additional","affiliation":[{"name":"Center for Fetal and Maternal Health Lucile Packard Children's Hospital Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie A.","family":"Manning","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics Department of Pediatrics Stanford University Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric A.","family":"Muller","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics Department of Pediatrics Stanford University Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna\u2010Kaisa","family":"Niemi","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics Department of Pediatrics Stanford University Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie H.","family":"Seaver","sequence":"additional","affiliation":[{"name":"Kapiolani Medical Specialties Honolulu Hawaii"},{"name":"Department of Pediatrics University of Hawaii John A. 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