{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:34:41Z","timestamp":1777480481429,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T00:00:00Z","timestamp":1413936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Nonsyndromic cleft lip with or without cleft palate (NSCLP) is a common congenital malformation with a worldwide prevalence rate of 0.4\u20132.0% among live births, depending on race and ethnic background. Single\u2010nucleotide polymorphisms (SNPs) of genes may contribute to NSCLP risk, although the risk factors and pathogenesis of NSCLP remain unknown. The objective of this study was to investigate association of SNPs of noggin (<jats:italic>NOG<\/jats:italic>) and sprouty homolog 2 (<jats:italic>SPRY2<\/jats:italic>) with NSCLP risk. A total of 188 NSCLP patients and 228 healthy controls from northern China were recruited for genotyping of these SNPs using the SNaP shot method. The frequency of the <jats:italic>NOG<\/jats:italic> rs227731 genotype was significantly lower among NSCLP cases than among controls. Logistic regression analysis showed rs227731 CC genotype was associated with decreased NSCLP susceptibility (OR\u2009=\u20090.31, 95% CI\u2009=\u20090.12\u20130.80) compared to the AA homozygote. However, no association between <jats:italic>SPRY2<\/jats:italic>, SNPs, and NSCLP risk were observed in this cohort of patients. In conclusion, <jats:italic>NOG<\/jats:italic> rs227731 genotype was associated with decreased NSCLP risk in a Northern Chinese population. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajmg.a.36802","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T17:57:53Z","timestamp":1414000673000},"page":"137-141","source":"Crossref","is-referenced-by-count":12,"title":["Association between <i>NOGGIN<\/i> and <i>SPRY2<\/i> polymorphisms and nonsyndromic cleft lip with or without cleft palate"],"prefix":"10.1002","volume":"167","author":[{"given":"Tao","family":"Song","sequence":"first","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital Harbin Medical University Harbin Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinna","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital Harbin Medical University 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