{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:42:03Z","timestamp":1793752923605,"version":"4.6.1"},"reference-count":74,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T00:00:00Z","timestamp":1414108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Morquio A syndrome (mucopolysaccharidosis IVA) is a lysosomal storage disorder associated with skeletal and joint abnormalities and significant non\u2010skeletal manifestations including respiratory disease, spinal cord compression, cardiac disease, impaired vision, hearing loss, and dental problems. The clinical presentation, onset, severity and progression rate of clinical manifestations of Morquio A syndrome vary widely between patients. Because of the heterogeneous and progressive nature of the disease, the management of patients with Morquio A syndrome is challenging and requires a multidisciplinary approach, involving an array of specialists. The current paper presents international guidelines for the evaluation, treatment and symptom\u2010based management of Morquio A syndrome. These guidelines were developed during two expert meetings by an international panel of specialists in pediatrics, genetics, orthopedics, pulmonology, cardiology, and anesthesia with extensive experience in managing Morquio A syndrome. \u00a9 2014 The Authors.\n                      <jats:italic>American Journal of Medical Genetics Part A<\/jats:italic>\n                      published by Wiley Periodicals, Inc.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajmg.a.36833","type":"journal-article","created":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T13:39:28Z","timestamp":1414157968000},"page":"11-25","source":"Crossref","is-referenced-by-count":124,"title":["International guidelines for the management and treatment of Morquio A syndrome"],"prefix":"10.1002","volume":"167","author":[{"given":"Christian J.","family":"Hendriksz","sequence":"first","affiliation":[{"name":"Salford Royal NHS Foundation Trust Salford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth I.","family":"Berger","sequence":"additional","affiliation":[{"name":"New York University School of Medicine New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Giugliani","sequence":"additional","affiliation":[{"name":"Department of Genetics\/UFRGS and INAGEMP Medical Genetics Service\/HCPA Porto Alegrw, RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Harmatz","sequence":"additional","affiliation":[{"name":"University of California San Francisco Benioff Children's Hospital Oakland Oakland California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Kampmann","sequence":"additional","affiliation":[{"name":"University Children's Hospital Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Mackenzie","sequence":"additional","affiliation":[{"name":"Nemours\/Alfred I. duPont Hospital for Children Wilmington Delaware"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Raiman","sequence":"additional","affiliation":[{"name":"Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha Solano","family":"Villarreal","sequence":"additional","affiliation":[{"name":"Fundacion Cardioinfantil Bogot\u00e1  C\/marca Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Savarirayan","sequence":"additional","affiliation":[{"name":"Murdoch Childrens Research Institute and University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-1130(03)80019-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200295"},{"key":"e_1_2_7_4_1","first-page":"45","article-title":"Current and emerging management options for patients with Morquio A syndrome","volume":"9","author":"Algahim MF","year":"2013","journal-title":"Ther Clin Risk Manag"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2005.11.007"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2010.02364.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/8904_2012_179"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.90B12.20641"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-012-9555-1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-011-9359-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210100605"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.74.6.382"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.06.001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2010.09.008"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01202412-200110000-00011"},{"key":"e_1_2_7_17_1","first-page":"349","article-title":"Retinal involvement in Morquio's syndrome (MPS IV)","volume":"17","author":"Dangel ME","year":"1985","journal-title":"Ann Ophthalmol"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-011-9430-5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.01135"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/BPB.0b013e32835a0e6d"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0b013e318259fe57"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2011.02280.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3233\/PRM-2010-0105","article-title":"Bone density assessment in patients with mucopolysaccharidosis: A preliminary report from patients with MPS II and VI","volume":"3","author":"Fung EB","year":"2010","journal-title":"J Pediatr Rehabil Med"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1023"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.12.014"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2013.01.021"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2011.11.076"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-012-9459-0"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2013.04.002"},{"key":"e_1_2_7_30_1","first-page":"69","article-title":"Transition services for adolescents with lysosomal storage disorders","volume":"11","author":"Hendriksz CJ","year":"2013","journal-title":"CML\u2010Lysosomal Storage Diseases"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545\u2010014\u20109715\u20106"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-9-32"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00920060"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/8904_2011_46"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000027420"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(90)90114-8"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-013-1797-y"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.055400"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197759030-00008"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.44.235.291"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.45.239.13"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.07.005"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/8904_2013_231"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32281"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-007-0529-7"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2014.03.004"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gim.0000232477.37660.fb"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004390050641"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20314"},{"key":"e_1_2_7_50_1","first-page":"3421","volume-title":"The metabolic and molecular bases of inherited disease","author":"Neufeld EF","year":"2001"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1532\/HSF98.20071197"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01230591"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.3109\/13816819309042908"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2008.12.009"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dbb571"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1197\/j.jht.2005.04.003"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.92B2.23104"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.78B2.0780307"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-4388.95586"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1977.00780260048003"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-263x.1999.00127.x"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200694"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-013-9586-2"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker392"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12306-008-0046-3"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2012.03904.x"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1998.tb02747.x"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20257"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm353"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920111795542615"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-012-9563-1"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCO.0b013e318269c313"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11832-014-0601-4"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-013-9587-1"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.01.046"}],"container-title":["American Journal of Medical Genetics Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.a.36833","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.36833","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajmg.a.36833","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.a.36833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T21:57:30Z","timestamp":1696629450000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.a.36833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,24]]},"references-count":74,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1002\/ajmg.a.36833"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.a.36833","archive":["Portico"],"relation":{},"ISSN":["1552-4825","1552-4833"],"issn-type":[{"value":"1552-4825","type":"print"},{"value":"1552-4833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,24]]}}}