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The primary topics discussed in this overview of the extant literature include the history of this condition and its diagnosis, the incidence of mosaicism, the meiotic and\/or mitotic chromosomal malsegregation events resulting in mosaicism, the observation of mosaicism in the parents of children with the non\u2010mosaic form of Down syndrome, and the variation in phenotypic outcome for both constitutional and acquired traits present in people with mosaicism for trisomy 21\/Down syndrome, including cognition, fertility, and overall phenotypic findings. Additional topics reviewed include the social conditions of people with mosaicism, as well as age\u2010related and epigenetic alterations observed in people with mosaicism for trisomy 21\/Down syndrome. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajmg.a.36861","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T12:07:12Z","timestamp":1416485232000},"page":"26-39","source":"Crossref","is-referenced-by-count":125,"title":["Mosaicism for trisomy 21: A review"],"prefix":"10.1002","volume":"167","author":[{"given":"Paulie","family":"Papavassiliou","sequence":"first","affiliation":[{"name":"Department of Human and Molecular Genetics Virginia Commonwealth University Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chariyawan","family":"Charalsawadi","sequence":"additional","affiliation":[{"name":"Department of Human and Molecular Genetics Virginia Commonwealth University Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Rafferty","sequence":"additional","affiliation":[{"name":"Department of Human and Molecular Genetics Virginia Commonwealth University Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Jackson\u2010Cook","sequence":"additional","affiliation":[{"name":"Department of Human and Molecular Genetics Virginia Commonwealth University Richmond Virginia"},{"name":"Department of Pathology Virginia Commonwealth University Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12530"},{"key":"e_1_2_11_3_1","first-page":"426","article-title":"Down syndrome: Clinical and cytogenetic analysis","volume":"15","author":"Ahmed I","year":"2005","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/520000"},{"key":"e_1_2_11_5_1","unstructured":"American College ofMedical Genetics. 2009 Edition Revised 01\/2010. 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